KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L
All Species:
30.3
Human Site:
T450
Identified Species:
55.56
UniProt:
Q8TF46
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TF46
NP_001137160.1
1054
120787
T450
M
C
E
M
P
V
N
T
P
E
S
P
W
K
V
Chimpanzee
Pan troglodytes
XP_001174669
1054
120822
T450
M
C
E
M
P
V
N
T
P
E
S
P
W
K
V
Rhesus Macaque
Macaca mulatta
XP_001110092
1054
120876
T450
M
C
E
M
P
V
N
T
P
E
N
P
W
K
V
Dog
Lupus familis
XP_535520
885
102054
V339
L
G
V
H
I
A
D
V
T
H
F
V
P
P
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8C0S1
1053
120265
T450
M
C
E
M
P
V
N
T
P
E
N
P
W
K
V
Rat
Rattus norvegicus
Q5U2P0
1054
120741
T450
M
C
E
M
P
V
N
T
A
E
N
P
W
K
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511394
1174
132085
T573
L
G
E
M
P
V
D
T
P
E
K
P
W
R
V
Chicken
Gallus gallus
XP_417016
963
109342
R413
D
G
W
P
R
N
S
R
Y
P
N
G
H
F
V
Frog
Xenopus laevis
Q6GN11
1040
119148
T445
L
A
E
M
P
S
N
T
H
E
N
P
W
Q
V
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
T444
L
R
E
M
P
V
N
T
E
E
N
P
W
Q
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17632
961
108768
H413
R
I
V
V
A
I
D
H
W
P
R
D
S
K
Y
Sea Urchin
Strong. purpuratus
XP_001200561
887
101086
T341
N
W
R
D
Y
V
A
T
F
P
E
K
D
E
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
P414
L
A
P
S
S
V
D
P
Q
S
S
S
T
Q
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98
77.9
N.A.
91.5
91.4
N.A.
65.2
33.8
68.6
64
N.A.
N.A.
N.A.
31.5
48.4
Protein Similarity:
100
99.8
98.9
81.3
N.A.
96.3
96.5
N.A.
74.8
53
81.6
79
N.A.
N.A.
N.A.
50.7
64.7
P-Site Identity:
100
100
93.3
0
N.A.
93.3
86.6
N.A.
66.6
6.6
60
60
N.A.
N.A.
N.A.
6.6
13.3
P-Site Similarity:
100
100
100
13.3
N.A.
100
93.3
N.A.
86.6
20
80
86.6
N.A.
N.A.
N.A.
26.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
49.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
0
0
8
8
8
0
8
0
0
0
0
0
0
% A
% Cys:
0
39
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
8
0
0
31
0
0
0
0
8
8
0
0
% D
% Glu:
0
0
62
0
0
0
0
0
8
62
8
0
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
8
0
8
0
0
8
0
% F
% Gly:
0
24
0
0
0
0
0
0
0
0
0
8
0
0
0
% G
% His:
0
0
0
8
0
0
0
8
8
8
0
0
8
0
0
% H
% Ile:
0
8
0
0
8
8
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
8
8
0
47
0
% K
% Leu:
39
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
39
0
0
62
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
8
0
0
0
0
8
54
0
0
0
47
0
0
0
8
% N
% Pro:
0
0
8
8
62
0
0
8
39
24
0
62
8
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
8
0
0
0
0
24
0
% Q
% Arg:
8
8
8
0
8
0
0
8
0
0
8
0
0
8
8
% R
% Ser:
0
0
0
8
8
8
8
0
0
8
24
8
8
0
8
% S
% Thr:
0
0
0
0
0
0
0
70
8
0
0
0
8
0
0
% T
% Val:
0
0
16
8
0
70
0
8
0
0
0
8
0
0
62
% V
% Trp:
0
8
8
0
0
0
0
0
8
0
0
0
62
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
8
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _