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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AEN All Species: 11.82
Human Site: S255 Identified Species: 28.89
UniProt: Q8WTP8 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.22
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8WTP8 NP_073604.3 325 36350 S255 V G Q H G H S S V E D A T T A
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_545846 324 36656 S255 A G Q H G H S S V E D A T T A
Cat Felis silvestris
Mouse Mus musculus Q9CZI9 336 37291 S254 V G H Q G H S S V E D A M T A
Rat Rattus norvegicus B2GUW6 332 37042 S250 V G H H G H S S V E D A M T A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521432 145 16419 L80 Q E A Q K E I L K L L R G K V
Chicken Gallus gallus XP_413869 301 33587 V236 L L Q K K I Q V G C K G H S S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001096663 321 36753 E254 N E K A G F P E K Q C V S L K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785830 225 25708 L160 T P G Q H L G L K S L A K Y L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8L7M4 567 62783 G479 L T C N K K S G L K K S N V S
Baker's Yeast Sacchar. cerevisiae Q08237 289 32876 D224 H P K S L L R D T S R H L P F
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 82.7 N.A. 71.4 73.8 N.A. 32 47.6 N.A. 41.2 N.A. N.A. N.A. N.A. 35.6
Protein Similarity: 100 N.A. N.A. 87.6 N.A. 78.2 79.8 N.A. 37.5 60 N.A. 56.3 N.A. N.A. N.A. N.A. 49.2
P-Site Identity: 100 N.A. N.A. 93.3 N.A. 80 86.6 N.A. 0 6.6 N.A. 6.6 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 N.A. N.A. 93.3 N.A. 80 86.6 N.A. 0 26.6 N.A. 26.6 N.A. N.A. N.A. N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. 21.5 27.6 N.A.
Protein Similarity: N.A. N.A. N.A. 32.8 44.3 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 46.6 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 10 10 0 0 0 0 0 0 0 50 0 0 40 % A
% Cys: 0 0 10 0 0 0 0 0 0 10 10 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 10 0 0 40 0 0 0 0 % D
% Glu: 0 20 0 0 0 10 0 10 0 40 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 10 % F
% Gly: 0 40 10 0 50 0 10 10 10 0 0 10 10 0 0 % G
% His: 10 0 20 30 10 40 0 0 0 0 0 10 10 0 0 % H
% Ile: 0 0 0 0 0 10 10 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 20 10 30 10 0 0 30 10 20 0 10 10 10 % K
% Leu: 20 10 0 0 10 20 0 20 10 10 20 0 10 10 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 20 0 0 % M
% Asn: 10 0 0 10 0 0 0 0 0 0 0 0 10 0 0 % N
% Pro: 0 20 0 0 0 0 10 0 0 0 0 0 0 10 0 % P
% Gln: 10 0 30 30 0 0 10 0 0 10 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 10 0 0 0 10 10 0 0 0 % R
% Ser: 0 0 0 10 0 0 50 40 0 20 0 10 10 10 20 % S
% Thr: 10 10 0 0 0 0 0 0 10 0 0 0 20 40 0 % T
% Val: 30 0 0 0 0 0 0 10 40 0 0 10 0 10 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _