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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FRS2 All Species: 25.76
Human Site: S177 Identified Species: 51.52
UniProt: Q8WU20 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8WU20 NP_001036020.1 508 57029 S177 V G S A R L P S V G E E S T H
Chimpanzee Pan troglodytes XP_522464 508 57026 S177 V G S A R L P S V G E E S T H
Rhesus Macaque Macaca mulatta XP_001084538 492 54416 S173 T S S L R H P S L G E E S T H
Dog Lupus familis XP_850500 508 57011 S177 V G S A R L P S V G E E S T H
Cat Felis silvestris
Mouse Mus musculus Q8C180 508 56775 S177 V G S A R L P S V G E E S T H
Rat Rattus norvegicus Q52RG8 492 54329 R164 P R F S S A P R R P S T S S L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518131 552 59439 S206 A G S L R H S S L G E E S T H
Chicken Gallus gallus XP_416087 508 57269 S177 V G S A R L P S V G E E S T H
Frog Xenopus laevis P07222 299 33514
Zebra Danio Brachydanio rerio XP_001923962 485 53928 S164 S R H P S V G S T R L P S V G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001122793 483 53108 G161 F V H N Q Q N G V G R L D S V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_781457 717 77816 G232 I P E S P L E G T P E D S L V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 48.2 99.2 N.A. 95.8 49.6 N.A. 42.5 92.7 20.8 65.3 N.A. N.A. 20.6 N.A. 25.8
Protein Similarity: 100 99.8 65.7 100 N.A. 98 64.9 N.A. 57.2 96.4 32.2 75 N.A. N.A. 37.2 N.A. 40.1
P-Site Identity: 100 100 66.6 100 N.A. 100 13.3 N.A. 66.6 100 0 13.3 N.A. N.A. 13.3 N.A. 20
P-Site Similarity: 100 100 73.3 100 N.A. 100 26.6 N.A. 73.3 100 0 20 N.A. N.A. 26.6 N.A. 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 0 42 0 9 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 9 9 0 0 % D
% Glu: 0 0 9 0 0 0 9 0 0 0 67 59 0 0 0 % E
% Phe: 9 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 50 0 0 0 0 9 17 0 67 0 0 0 0 9 % G
% His: 0 0 17 0 0 17 0 0 0 0 0 0 0 0 59 % H
% Ile: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 17 0 50 0 0 17 0 9 9 0 9 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 9 0 0 9 0 0 0 0 0 0 0 0 % N
% Pro: 9 9 0 9 9 0 59 0 0 17 0 9 0 0 0 % P
% Gln: 0 0 0 0 9 9 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 17 0 0 59 0 0 9 9 9 9 0 0 0 0 % R
% Ser: 9 9 59 17 17 0 9 67 0 0 9 0 84 17 0 % S
% Thr: 9 0 0 0 0 0 0 0 17 0 0 9 0 59 0 % T
% Val: 42 9 0 0 0 9 0 0 50 0 0 0 0 9 17 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _