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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FRS2
All Species:
17.88
Human Site:
S221
Identified Species:
35.76
UniProt:
Q8WU20
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WU20
NP_001036020.1
508
57029
S221
V
P
L
E
A
R
V
S
N
A
E
S
S
T
P
Chimpanzee
Pan troglodytes
XP_522464
508
57026
S221
V
P
L
E
A
R
V
S
N
A
E
S
N
T
P
Rhesus Macaque
Macaca mulatta
XP_001084538
492
54416
A217
Q
P
L
P
E
G
Q
A
P
F
L
S
Q
A
R
Dog
Lupus familis
XP_850500
508
57011
S221
V
P
L
E
A
R
I
S
N
A
E
S
N
T
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8C180
508
56775
S221
V
P
P
E
A
R
V
S
N
A
E
S
N
T
P
Rat
Rattus norvegicus
Q52RG8
492
54329
H208
E
E
D
R
R
S
R
H
C
L
Q
P
L
P
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518131
552
59439
P250
V
G
T
T
L
F
S
P
L
R
P
G
T
P
L
Chicken
Gallus gallus
XP_416087
508
57269
S221
A
P
L
E
S
K
L
S
N
T
E
T
T
K
V
Frog
Xenopus laevis
P07222
299
33514
K25
F
L
F
G
C
E
L
K
A
D
K
K
E
Y
S
Zebra Danio
Brachydanio rerio
XP_001923962
485
53928
L208
R
S
T
G
H
T
P
L
E
P
E
T
S
N
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001122793
483
53108
S205
P
F
P
Q
P
H
P
S
S
L
Y
V
N
E
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781457
717
77816
N276
L
P
S
D
E
D
K
N
N
G
G
D
A
Q
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
48.2
99.2
N.A.
95.8
49.6
N.A.
42.5
92.7
20.8
65.3
N.A.
N.A.
20.6
N.A.
25.8
Protein Similarity:
100
99.8
65.7
100
N.A.
98
64.9
N.A.
57.2
96.4
32.2
75
N.A.
N.A.
37.2
N.A.
40.1
P-Site Identity:
100
93.3
20
86.6
N.A.
86.6
0
N.A.
6.6
40
0
13.3
N.A.
N.A.
6.6
N.A.
13.3
P-Site Similarity:
100
100
26.6
100
N.A.
93.3
6.6
N.A.
13.3
73.3
13.3
20
N.A.
N.A.
26.6
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
34
0
0
9
9
34
0
0
9
9
0
% A
% Cys:
0
0
0
0
9
0
0
0
9
0
0
0
0
0
0
% C
% Asp:
0
0
9
9
0
9
0
0
0
9
0
9
0
0
0
% D
% Glu:
9
9
0
42
17
9
0
0
9
0
50
0
9
9
17
% E
% Phe:
9
9
9
0
0
9
0
0
0
9
0
0
0
0
0
% F
% Gly:
0
9
0
17
0
9
0
0
0
9
9
9
0
0
0
% G
% His:
0
0
0
0
9
9
0
9
0
0
0
0
0
0
9
% H
% Ile:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
9
9
9
0
0
9
9
0
9
0
% K
% Leu:
9
9
42
0
9
0
17
9
9
17
9
0
9
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
9
50
0
0
0
34
9
0
% N
% Pro:
9
59
17
9
9
0
17
9
9
9
9
9
0
17
34
% P
% Gln:
9
0
0
9
0
0
9
0
0
0
9
0
9
9
9
% Q
% Arg:
9
0
0
9
9
34
9
0
0
9
0
0
0
0
9
% R
% Ser:
0
9
9
0
9
9
9
50
9
0
0
42
17
0
9
% S
% Thr:
0
0
17
9
0
9
0
0
0
9
0
17
17
34
0
% T
% Val:
42
0
0
0
0
0
25
0
0
0
0
9
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
9
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _