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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FRS2 All Species: 19.7
Human Site: S292 Identified Species: 39.39
UniProt: Q8WU20 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8WU20 NP_001036020.1 508 57029 S292 E W D T G Y D S D E R R D A P
Chimpanzee Pan troglodytes XP_522464 508 57026 S292 E W D T G Y D S D E R R D A P
Rhesus Macaque Macaca mulatta XP_001084538 492 54416 P276 H N N N N E A P S E C P A Q P
Dog Lupus familis XP_850500 508 57011 S292 E W D T G Y D S D E R R D A P
Cat Felis silvestris
Mouse Mus musculus Q8C180 508 56775 S292 E W D T G Y D S D E R R D V P
Rat Rattus norvegicus Q52RG8 492 54329 P276 L H N N N E G P S E C P A Q P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518131 552 59439 G336 E N V T G P P G R G A G W R L
Chicken Gallus gallus XP_416087 508 57269 S292 E W D T G Y D S D E R R E T P
Frog Xenopus laevis P07222 299 33514 P83 I A L A S L K P S V Q P T V S
Zebra Danio Brachydanio rerio XP_001923962 485 53928 P269 S E H T S Y T P P V K T V N G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001122793 483 53108 S268 E I T S Q I K S P L S I A T Y
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_781457 717 77816 S438 K N G K R E V S D I E R T T A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 48.2 99.2 N.A. 95.8 49.6 N.A. 42.5 92.7 20.8 65.3 N.A. N.A. 20.6 N.A. 25.8
Protein Similarity: 100 99.8 65.7 100 N.A. 98 64.9 N.A. 57.2 96.4 32.2 75 N.A. N.A. 37.2 N.A. 40.1
P-Site Identity: 100 100 13.3 100 N.A. 93.3 13.3 N.A. 20 86.6 0 13.3 N.A. N.A. 13.3 N.A. 20
P-Site Similarity: 100 100 20 100 N.A. 93.3 20 N.A. 20 93.3 6.6 20 N.A. N.A. 20 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 0 9 0 0 9 0 0 0 9 0 25 25 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 17 0 0 0 0 % C
% Asp: 0 0 42 0 0 0 42 0 50 0 0 0 34 0 0 % D
% Glu: 59 9 0 0 0 25 0 0 0 59 9 0 9 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 9 0 50 0 9 9 0 9 0 9 0 0 9 % G
% His: 9 9 9 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 9 9 0 0 0 9 0 0 0 9 0 9 0 0 0 % I
% Lys: 9 0 0 9 0 0 17 0 0 0 9 0 0 0 0 % K
% Leu: 9 0 9 0 0 9 0 0 0 9 0 0 0 0 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 25 17 17 17 0 0 0 0 0 0 0 0 9 0 % N
% Pro: 0 0 0 0 0 9 9 34 17 0 0 25 0 0 59 % P
% Gln: 0 0 0 0 9 0 0 0 0 0 9 0 0 17 0 % Q
% Arg: 0 0 0 0 9 0 0 0 9 0 42 50 0 9 0 % R
% Ser: 9 0 0 9 17 0 0 59 25 0 9 0 0 0 9 % S
% Thr: 0 0 9 59 0 0 9 0 0 0 0 9 17 25 0 % T
% Val: 0 0 9 0 0 0 9 0 0 17 0 0 9 17 0 % V
% Trp: 0 42 0 0 0 0 0 0 0 0 0 0 9 0 0 % W
% Tyr: 0 0 0 0 0 50 0 0 0 0 0 0 0 0 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _