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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FRS2
All Species:
21.52
Human Site:
S447
Identified Species:
43.03
UniProt:
Q8WU20
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WU20
NP_001036020.1
508
57029
S447
D
L
E
G
G
S
D
S
D
N
P
Q
T
P
K
Chimpanzee
Pan troglodytes
XP_522464
508
57026
S447
D
L
E
G
G
S
D
S
D
N
P
Q
T
P
K
Rhesus Macaque
Macaca mulatta
XP_001084538
492
54416
K431
G
W
G
G
D
R
P
K
G
P
Q
N
P
S
S
Dog
Lupus familis
XP_850500
508
57011
S447
D
L
E
G
G
S
D
S
D
N
P
Q
T
P
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8C180
508
56775
S447
D
L
E
G
G
S
D
S
D
N
P
Q
T
P
K
Rat
Rattus norvegicus
Q52RG8
492
54329
K431
G
W
G
T
A
H
P
K
G
P
Q
N
P
S
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518131
552
59439
Q491
D
A
P
R
A
G
L
Q
S
P
G
V
P
W
A
Chicken
Gallus gallus
XP_416087
508
57269
S447
D
L
E
G
G
S
D
S
D
N
P
Q
T
P
K
Frog
Xenopus laevis
P07222
299
33514
T238
T
K
P
Q
T
P
K
T
P
K
T
P
L
S
S
Zebra Danio
Brachydanio rerio
XP_001923962
485
53928
S424
E
M
D
K
V
S
D
S
S
G
P
H
T
P
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001122793
483
53108
L423
P
P
E
S
P
N
K
L
Q
K
G
Y
A
T
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781457
717
77816
R593
L
P
E
V
Q
P
L
R
H
S
L
S
S
N
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
48.2
99.2
N.A.
95.8
49.6
N.A.
42.5
92.7
20.8
65.3
N.A.
N.A.
20.6
N.A.
25.8
Protein Similarity:
100
99.8
65.7
100
N.A.
98
64.9
N.A.
57.2
96.4
32.2
75
N.A.
N.A.
37.2
N.A.
40.1
P-Site Identity:
100
100
6.6
100
N.A.
100
0
N.A.
6.6
100
0
46.6
N.A.
N.A.
6.6
N.A.
6.6
P-Site Similarity:
100
100
6.6
100
N.A.
100
0
N.A.
6.6
100
6.6
66.6
N.A.
N.A.
13.3
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
17
0
0
0
0
0
0
0
9
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
50
0
9
0
9
0
50
0
42
0
0
0
0
0
0
% D
% Glu:
9
0
59
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
17
0
17
50
42
9
0
0
17
9
17
0
0
0
9
% G
% His:
0
0
0
0
0
9
0
0
9
0
0
9
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% I
% Lys:
0
9
0
9
0
0
17
17
0
17
0
0
0
0
50
% K
% Leu:
9
42
0
0
0
0
17
9
0
0
9
0
9
0
0
% L
% Met:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
9
0
0
0
42
0
17
0
9
0
% N
% Pro:
9
17
17
0
9
17
17
0
9
25
50
9
25
50
0
% P
% Gln:
0
0
0
9
9
0
0
9
9
0
17
42
0
0
0
% Q
% Arg:
0
0
0
9
0
9
0
9
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
9
0
50
0
50
17
9
0
9
9
25
17
% S
% Thr:
9
0
0
9
9
0
0
9
0
0
9
0
50
9
0
% T
% Val:
0
0
0
9
9
0
0
0
0
0
0
9
0
0
9
% V
% Trp:
0
17
0
0
0
0
0
0
0
0
0
0
0
9
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _