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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FRS2
All Species:
22.12
Human Site:
T458
Identified Species:
44.24
UniProt:
Q8WU20
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WU20
NP_001036020.1
508
57029
T458
Q
T
P
K
T
P
T
T
P
L
P
Q
T
P
T
Chimpanzee
Pan troglodytes
XP_522464
508
57026
T458
Q
T
P
K
T
P
T
T
P
L
P
Q
T
P
T
Rhesus Macaque
Macaca mulatta
XP_001084538
492
54416
P442
N
P
S
S
P
Q
A
P
M
P
T
T
H
P
A
Dog
Lupus familis
XP_850500
508
57011
T458
Q
T
P
K
T
P
T
T
P
L
P
Q
T
P
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8C180
508
56775
T458
Q
T
P
K
T
P
T
T
P
L
P
Q
T
P
T
Rat
Rattus norvegicus
Q52RG8
492
54329
P442
N
P
S
V
S
G
A
P
G
P
T
P
H
P
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518131
552
59439
A502
V
P
W
A
L
G
P
A
P
T
A
P
T
P
A
Chicken
Gallus gallus
XP_416087
508
57269
T458
Q
T
P
K
T
P
T
T
P
L
P
Q
T
P
T
Frog
Xenopus laevis
P07222
299
33514
K249
P
L
S
S
E
E
I
K
A
K
M
Q
T
Y
L
Zebra Danio
Brachydanio rerio
XP_001923962
485
53928
T435
H
T
P
K
T
P
T
T
P
L
P
A
T
P
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001122793
483
53108
K434
Y
A
T
I
D
F
N
K
T
A
A
L
S
H
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781457
717
77816
N604
S
S
N
G
A
A
T
N
G
A
G
N
W
M
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
48.2
99.2
N.A.
95.8
49.6
N.A.
42.5
92.7
20.8
65.3
N.A.
N.A.
20.6
N.A.
25.8
Protein Similarity:
100
99.8
65.7
100
N.A.
98
64.9
N.A.
57.2
96.4
32.2
75
N.A.
N.A.
37.2
N.A.
40.1
P-Site Identity:
100
100
6.6
100
N.A.
100
6.6
N.A.
20
100
13.3
86.6
N.A.
N.A.
0
N.A.
6.6
P-Site Similarity:
100
100
6.6
100
N.A.
100
13.3
N.A.
20
100
13.3
86.6
N.A.
N.A.
13.3
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
9
9
9
17
9
9
17
17
9
0
0
25
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
9
9
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
9
0
17
0
0
17
0
9
0
0
0
0
% G
% His:
9
0
0
0
0
0
0
0
0
0
0
0
17
9
0
% H
% Ile:
0
0
0
9
0
0
9
0
0
0
0
0
0
0
9
% I
% Lys:
0
0
0
50
0
0
0
17
0
9
0
0
0
0
0
% K
% Leu:
0
9
0
0
9
0
0
0
0
50
0
9
0
0
9
% L
% Met:
0
0
0
0
0
0
0
0
9
0
9
0
0
9
0
% M
% Asn:
17
0
9
0
0
0
9
9
0
0
0
9
0
0
0
% N
% Pro:
9
25
50
0
9
50
9
17
59
17
50
17
0
75
0
% P
% Gln:
42
0
0
0
0
9
0
0
0
0
0
50
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
9
9
25
17
9
0
0
0
0
0
0
0
9
0
9
% S
% Thr:
0
50
9
0
50
0
59
50
9
9
17
9
67
0
50
% T
% Val:
9
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
9
0
0
0
0
0
0
0
0
0
9
0
0
% W
% Tyr:
9
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _