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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FRS2
All Species:
33.64
Human Site:
Y471
Identified Species:
67.27
UniProt:
Q8WU20
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WU20
NP_001036020.1
508
57029
Y471
P
T
R
R
T
E
L
Y
A
V
I
D
I
E
R
Chimpanzee
Pan troglodytes
XP_522464
508
57026
Y471
P
T
R
R
T
E
L
Y
A
V
I
D
I
E
R
Rhesus Macaque
Macaca mulatta
XP_001084538
492
54416
Y455
P
A
R
S
S
D
S
Y
A
V
I
D
L
K
K
Dog
Lupus familis
XP_850500
508
57011
Y471
P
T
R
R
T
E
L
Y
A
V
I
D
I
E
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8C180
508
56775
Y471
P
T
R
R
T
E
L
Y
A
V
I
D
I
E
R
Rat
Rattus norvegicus
Q52RG8
492
54329
Y455
P
A
R
S
S
D
S
Y
A
V
I
D
L
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518131
552
59439
Y515
P
A
R
R
V
D
S
Y
A
V
I
D
L
K
K
Chicken
Gallus gallus
XP_416087
508
57269
Y471
P
T
R
R
T
E
L
Y
A
V
I
D
I
E
R
Frog
Xenopus laevis
P07222
299
33514
L262
Y
L
E
K
G
N
V
L
P
K
V
E
V
K
F
Zebra Danio
Brachydanio rerio
XP_001923962
485
53928
Y448
P
T
R
R
T
E
L
Y
A
V
I
D
I
E
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001122793
483
53108
V447
H
S
V
N
P
N
I
V
N
D
N
E
G
S
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781457
717
77816
K617
M
I
L
Q
P
P
P
K
G
K
V
N
Y
I
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
48.2
99.2
N.A.
95.8
49.6
N.A.
42.5
92.7
20.8
65.3
N.A.
N.A.
20.6
N.A.
25.8
Protein Similarity:
100
99.8
65.7
100
N.A.
98
64.9
N.A.
57.2
96.4
32.2
75
N.A.
N.A.
37.2
N.A.
40.1
P-Site Identity:
100
100
46.6
100
N.A.
100
46.6
N.A.
53.3
100
0
100
N.A.
N.A.
6.6
N.A.
0
P-Site Similarity:
100
100
80
100
N.A.
100
80
N.A.
80
100
40
100
N.A.
N.A.
26.6
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
25
0
0
0
0
0
0
75
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
25
0
0
0
9
0
75
0
0
0
% D
% Glu:
0
0
9
0
0
50
0
0
0
0
0
17
0
50
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% F
% Gly:
0
0
0
0
9
0
0
0
9
0
0
0
9
0
0
% G
% His:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
9
0
0
0
0
9
0
0
0
75
0
50
9
0
% I
% Lys:
0
0
0
9
0
0
0
9
0
17
0
0
0
34
25
% K
% Leu:
0
9
9
0
0
0
50
9
0
0
0
0
25
0
0
% L
% Met:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
9
0
17
0
0
9
0
9
9
0
0
0
% N
% Pro:
75
0
0
0
17
9
9
0
9
0
0
0
0
0
0
% P
% Gln:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
9
% Q
% Arg:
0
0
75
59
0
0
0
0
0
0
0
0
0
0
59
% R
% Ser:
0
9
0
17
17
0
25
0
0
0
0
0
0
9
0
% S
% Thr:
0
50
0
0
50
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
9
0
9
0
9
9
0
75
17
0
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
0
0
0
75
0
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _