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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TWIST2
All Species:
36.06
Human Site:
T106
Identified Species:
66.11
UniProt:
Q8WVJ9
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WVJ9
NP_476527.1
160
18124
T106
D
K
L
S
K
I
Q
T
L
K
L
A
A
R
Y
Chimpanzee
Pan troglodytes
Q8MI03
201
20743
I147
P
S
D
K
L
S
K
I
Q
T
L
K
L
A
A
Rhesus Macaque
Macaca mulatta
XP_001103003
192
19946
T138
D
K
L
S
K
I
Q
T
L
K
L
A
A
R
Y
Dog
Lupus familis
XP_862780
160
17657
T106
D
K
L
S
K
I
Q
T
L
K
L
A
A
R
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q9D030
160
18122
T106
D
K
L
S
K
I
Q
T
L
K
L
A
A
R
Y
Rat
Rattus norvegicus
P97831
160
18106
T106
D
K
L
S
K
I
Q
T
L
K
L
A
A
R
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510876
214
24100
T160
D
K
L
S
K
I
Q
T
L
K
L
A
A
R
Y
Chicken
Gallus gallus
P79782
183
20177
F130
C
E
D
G
Q
P
C
F
S
A
I
Y
G
A
K
Frog
Xenopus laevis
P13903
166
18778
T112
D
K
L
S
K
I
Q
T
L
K
L
A
S
R
Y
Zebra Danio
Brachydanio rerio
Q7ZSX3
265
30428
D155
E
K
R
L
S
K
V
D
T
L
R
L
A
I
G
Tiger Blowfish
Takifugu rubipres
Q90YI8
371
40876
E244
D
K
K
L
S
K
N
E
I
L
R
L
A
M
K
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
NP_001011637
366
42484
T293
D
K
L
S
K
I
Q
T
L
K
L
A
T
R
Y
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001186660
334
37496
T279
D
K
L
S
K
I
Q
T
L
K
L
A
S
R
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
65.1
59.3
75
N.A.
99.3
100
N.A.
72.9
28.4
78.3
26.4
20.4
N.A.
31.9
N.A.
34.7
Protein Similarity:
100
72.1
65.6
81.2
N.A.
100
100
N.A.
73.8
39.8
85.5
37.7
30.7
N.A.
38.7
N.A.
41.3
P-Site Identity:
100
6.6
100
100
N.A.
100
100
N.A.
100
0
93.3
13.3
20
N.A.
93.3
N.A.
93.3
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
100
20
100
20
26.6
N.A.
93.3
N.A.
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
8
0
70
62
16
8
% A
% Cys:
8
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
77
0
16
0
0
0
0
8
0
0
0
0
0
0
0
% D
% Glu:
8
8
0
0
0
0
0
8
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
0
0
0
0
0
0
0
8
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
70
0
8
8
0
8
0
0
8
0
% I
% Lys:
0
85
8
8
70
16
8
0
0
70
0
8
0
0
16
% K
% Leu:
0
0
70
16
8
0
0
0
70
16
77
16
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% N
% Pro:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
8
0
70
0
8
0
0
0
0
0
0
% Q
% Arg:
0
0
8
0
0
0
0
0
0
0
16
0
0
70
0
% R
% Ser:
0
8
0
70
16
8
0
0
8
0
0
0
16
0
0
% S
% Thr:
0
0
0
0
0
0
0
70
8
8
0
0
8
0
0
% T
% Val:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
70
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _