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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGB4
All Species:
12.42
Human Site:
S132
Identified Species:
22.78
UniProt:
Q8WW32
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WW32
NP_660206
186
22405
S132
K
A
T
G
K
M
W
S
T
A
T
D
L
E
K
Chimpanzee
Pan troglodytes
Q9N1Q7
215
24747
A159
D
D
V
V
K
K
L
A
G
M
W
N
N
T
A
Rhesus Macaque
Macaca mulatta
XP_001107984
191
23044
S134
K
A
T
G
K
M
W
S
A
T
T
D
L
E
K
Dog
Lupus familis
XP_851529
191
22584
S132
K
A
S
G
R
M
W
S
V
T
S
G
A
E
K
Cat
Felis silvestris
Mouse
Mus musculus
Q6P8W9
181
21585
G128
V
Q
V
A
K
A
A
G
K
M
W
S
T
T
D
Rat
Rattus norvegicus
P52925
210
24140
S134
K
K
L
G
E
M
W
S
E
Q
S
A
K
D
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P26584
207
23809
S134
K
K
L
G
E
M
W
S
E
Q
L
A
K
D
K
Frog
Xenopus laevis
NP_001079576
212
24227
A135
K
K
L
G
E
L
W
A
E
Q
T
P
K
D
K
Zebra Danio
Brachydanio rerio
NP_001017769
198
22534
N133
K
K
L
G
G
M
W
N
N
L
S
D
S
E
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09390
235
27301
K174
Q
E
L
G
K
M
W
K
L
V
P
Q
E
T
K
Sea Urchin
Strong. purpuratus
P40644
200
22815
R139
K
E
L
A
V
R
W
R
A
M
T
A
G
E
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P11633
99
11557
R46
N
E
N
R
D
I
V
R
S
E
N
P
D
V
T
Red Bread Mold
Neurospora crassa
Q7S045
103
11590
G50
N
V
R
E
E
N
P
G
V
S
F
G
Q
V
G
Conservation
Percent
Protein Identity:
100
29.7
93.7
79
N.A.
71.5
38.5
N.A.
N.A.
39.1
37.2
37.3
N.A.
N.A.
N.A.
28.5
31
Protein Similarity:
100
48.3
95.2
86.9
N.A.
85.4
56.6
N.A.
N.A.
57.9
55.1
55.5
N.A.
N.A.
N.A.
44.2
52
P-Site Identity:
100
6.6
86.6
53.3
N.A.
6.6
40
N.A.
N.A.
40
33.3
46.6
N.A.
N.A.
N.A.
33.3
33.3
P-Site Similarity:
100
20
86.6
73.3
N.A.
6.6
60
N.A.
N.A.
53.3
60
60
N.A.
N.A.
N.A.
40
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.5
23.6
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
32.2
36
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
24
0
16
0
8
8
16
16
8
0
24
8
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
0
0
8
0
0
0
0
0
0
24
8
24
8
% D
% Glu:
0
24
0
8
31
0
0
0
24
8
0
0
8
39
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% F
% Gly:
0
0
0
62
8
0
0
16
8
0
0
16
8
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% I
% Lys:
62
31
0
0
39
8
0
8
8
0
0
0
24
0
70
% K
% Leu:
0
0
47
0
0
8
8
0
8
8
8
0
16
0
0
% L
% Met:
0
0
0
0
0
54
0
0
0
24
0
0
0
0
0
% M
% Asn:
16
0
8
0
0
8
0
8
8
0
8
8
8
0
0
% N
% Pro:
0
0
0
0
0
0
8
0
0
0
8
16
0
0
0
% P
% Gln:
8
8
0
0
0
0
0
0
0
24
0
8
8
0
0
% Q
% Arg:
0
0
8
8
8
8
0
16
0
0
0
0
0
0
0
% R
% Ser:
0
0
8
0
0
0
0
39
8
8
24
8
8
0
0
% S
% Thr:
0
0
16
0
0
0
0
0
8
16
31
0
8
24
8
% T
% Val:
8
8
16
8
8
0
8
0
16
8
0
0
0
16
0
% V
% Trp:
0
0
0
0
0
0
70
0
0
0
16
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _