KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGB4
All Species:
5.15
Human Site:
S173
Identified Species:
9.44
UniProt:
Q8WW32
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WW32
NP_660206
186
22405
S173
A
R
K
K
Y
R
M
S
A
R
N
R
C
R
G
Chimpanzee
Pan troglodytes
Q9N1Q7
215
24747
A200
A
K
G
K
P
N
S
A
T
K
R
V
V
K
A
Rhesus Macaque
Macaca mulatta
XP_001107984
191
23044
Y175
Q
C
N
A
R
K
K
Y
R
M
S
A
R
K
R
Dog
Lupus familis
XP_851529
191
22584
S173
T
R
K
G
L
Q
G
S
P
K
N
E
R
R
G
Cat
Felis silvestris
Mouse
Mus musculus
Q6P8W9
181
21585
G169
N
Q
C
Q
G
R
K
G
N
F
L
E
S
A
K
Rat
Rattus norvegicus
P52925
210
24140
P175
S
E
V
G
K
K
G
P
G
R
P
T
G
S
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P26584
207
23809
P175
S
D
A
G
K
K
G
P
G
R
P
A
G
S
K
Frog
Xenopus laevis
NP_001079576
212
24227
P176
S
D
V
G
K
K
V
P
G
R
A
T
G
S
K
Zebra Danio
Brachydanio rerio
NP_001017769
198
22534
S174
G
G
S
S
S
A
K
S
E
P
K
D
D
D
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09390
235
27301
Y215
K
M
S
G
M
D
H
Y
D
D
D
N
I
H
H
Sea Urchin
Strong. purpuratus
P40644
200
22815
E180
P
M
K
R
Q
V
K
E
S
S
S
S
S
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P11633
99
11557
Y87
A
Q
A
D
K
K
R
Y
E
S
E
K
E
L
Y
Red Bread Mold
Neurospora crassa
Q7S045
103
11590
Q91
K
R
Y
E
D
E
K
Q
A
Y
N
A
E
A
D
Conservation
Percent
Protein Identity:
100
29.7
93.7
79
N.A.
71.5
38.5
N.A.
N.A.
39.1
37.2
37.3
N.A.
N.A.
N.A.
28.5
31
Protein Similarity:
100
48.3
95.2
86.9
N.A.
85.4
56.6
N.A.
N.A.
57.9
55.1
55.5
N.A.
N.A.
N.A.
44.2
52
P-Site Identity:
100
13.3
0
40
N.A.
6.6
6.6
N.A.
N.A.
6.6
6.6
6.6
N.A.
N.A.
N.A.
0
6.6
P-Site Similarity:
100
40
20
53.3
N.A.
20
20
N.A.
N.A.
20
26.6
6.6
N.A.
N.A.
N.A.
6.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.5
23.6
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
32.2
36
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
20
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
24
0
16
8
0
8
0
8
16
0
8
24
0
16
8
% A
% Cys:
0
8
8
0
0
0
0
0
0
0
0
0
8
0
0
% C
% Asp:
0
16
0
8
8
8
0
0
8
8
8
8
8
8
16
% D
% Glu:
0
8
0
8
0
8
0
8
16
0
8
16
16
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
8
8
8
39
8
0
24
8
24
0
0
0
24
0
16
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
8
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% I
% Lys:
16
8
24
16
31
39
39
0
0
16
8
8
0
16
31
% K
% Leu:
0
0
0
0
8
0
0
0
0
0
8
0
0
8
0
% L
% Met:
0
16
0
0
8
0
8
0
0
8
0
0
0
0
0
% M
% Asn:
8
0
8
0
0
8
0
0
8
0
24
8
0
0
0
% N
% Pro:
8
0
0
0
8
0
0
24
8
8
16
0
0
0
0
% P
% Gln:
8
16
0
8
8
8
0
8
0
0
0
0
0
0
0
% Q
% Arg:
0
24
0
8
8
16
8
0
8
31
8
8
16
16
8
% R
% Ser:
24
0
16
8
8
0
8
24
8
16
16
8
16
31
8
% S
% Thr:
8
0
0
0
0
0
0
0
8
0
0
16
0
0
0
% T
% Val:
0
0
16
0
0
8
8
0
0
0
0
8
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
8
0
0
24
0
8
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _