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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGB4 All Species: 5.15
Human Site: S173 Identified Species: 9.44
UniProt: Q8WW32 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8WW32 NP_660206 186 22405 S173 A R K K Y R M S A R N R C R G
Chimpanzee Pan troglodytes Q9N1Q7 215 24747 A200 A K G K P N S A T K R V V K A
Rhesus Macaque Macaca mulatta XP_001107984 191 23044 Y175 Q C N A R K K Y R M S A R K R
Dog Lupus familis XP_851529 191 22584 S173 T R K G L Q G S P K N E R R G
Cat Felis silvestris
Mouse Mus musculus Q6P8W9 181 21585 G169 N Q C Q G R K G N F L E S A K
Rat Rattus norvegicus P52925 210 24140 P175 S E V G K K G P G R P T G S K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P26584 207 23809 P175 S D A G K K G P G R P A G S K
Frog Xenopus laevis NP_001079576 212 24227 P176 S D V G K K V P G R A T G S K
Zebra Danio Brachydanio rerio NP_001017769 198 22534 S174 G G S S S A K S E P K D D D D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q09390 235 27301 Y215 K M S G M D H Y D D D N I H H
Sea Urchin Strong. purpuratus P40644 200 22815 E180 P M K R Q V K E S S S S S S S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P11633 99 11557 Y87 A Q A D K K R Y E S E K E L Y
Red Bread Mold Neurospora crassa Q7S045 103 11590 Q91 K R Y E D E K Q A Y N A E A D
Conservation
Percent
Protein Identity: 100 29.7 93.7 79 N.A. 71.5 38.5 N.A. N.A. 39.1 37.2 37.3 N.A. N.A. N.A. 28.5 31
Protein Similarity: 100 48.3 95.2 86.9 N.A. 85.4 56.6 N.A. N.A. 57.9 55.1 55.5 N.A. N.A. N.A. 44.2 52
P-Site Identity: 100 13.3 0 40 N.A. 6.6 6.6 N.A. N.A. 6.6 6.6 6.6 N.A. N.A. N.A. 0 6.6
P-Site Similarity: 100 40 20 53.3 N.A. 20 20 N.A. N.A. 20 26.6 6.6 N.A. N.A. N.A. 6.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.5 23.6
Protein Similarity: N.A. N.A. N.A. N.A. 32.2 36
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 20
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 24 0 16 8 0 8 0 8 16 0 8 24 0 16 8 % A
% Cys: 0 8 8 0 0 0 0 0 0 0 0 0 8 0 0 % C
% Asp: 0 16 0 8 8 8 0 0 8 8 8 8 8 8 16 % D
% Glu: 0 8 0 8 0 8 0 8 16 0 8 16 16 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % F
% Gly: 8 8 8 39 8 0 24 8 24 0 0 0 24 0 16 % G
% His: 0 0 0 0 0 0 8 0 0 0 0 0 0 8 8 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % I
% Lys: 16 8 24 16 31 39 39 0 0 16 8 8 0 16 31 % K
% Leu: 0 0 0 0 8 0 0 0 0 0 8 0 0 8 0 % L
% Met: 0 16 0 0 8 0 8 0 0 8 0 0 0 0 0 % M
% Asn: 8 0 8 0 0 8 0 0 8 0 24 8 0 0 0 % N
% Pro: 8 0 0 0 8 0 0 24 8 8 16 0 0 0 0 % P
% Gln: 8 16 0 8 8 8 0 8 0 0 0 0 0 0 0 % Q
% Arg: 0 24 0 8 8 16 8 0 8 31 8 8 16 16 8 % R
% Ser: 24 0 16 8 8 0 8 24 8 16 16 8 16 31 8 % S
% Thr: 8 0 0 0 0 0 0 0 8 0 0 16 0 0 0 % T
% Val: 0 0 16 0 0 8 8 0 0 0 0 8 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 8 0 0 24 0 8 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _