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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGB4
All Species:
28.48
Human Site:
S53
Identified Species:
52.22
UniProt:
Q8WW32
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WW32
NP_660206
186
22405
S53
S
E
K
W
R
S
I
S
K
H
E
K
A
K
Y
Chimpanzee
Pan troglodytes
Q9N1Q7
215
24747
F82
S
E
M
W
K
T
I
F
A
K
E
K
G
K
F
Rhesus Macaque
Macaca mulatta
XP_001107984
191
23044
S55
S
E
K
W
R
S
I
S
K
H
E
K
A
K
Y
Dog
Lupus familis
XP_851529
191
22584
S53
S
E
K
W
R
S
I
S
K
H
E
K
A
K
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q6P8W9
181
21585
S53
S
E
K
W
R
S
I
S
K
H
E
K
A
K
Y
Rat
Rattus norvegicus
P52925
210
24140
S53
S
E
R
W
K
T
M
S
A
K
E
K
S
K
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P26584
207
23809
S53
S
E
R
W
K
T
M
S
S
K
E
K
G
K
F
Frog
Xenopus laevis
NP_001079576
212
24227
S53
S
E
R
W
K
S
M
S
A
K
E
K
G
K
F
Zebra Danio
Brachydanio rerio
NP_001017769
198
22534
S53
S
E
R
W
K
T
M
S
P
K
E
K
T
K
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09390
235
27301
V89
S
E
K
W
K
T
M
V
D
D
E
K
R
R
F
Sea Urchin
Strong. purpuratus
P40644
200
22815
E55
S
A
R
W
K
A
L
E
E
K
G
K
G
V
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P11633
99
11557
Red Bread Mold
Neurospora crassa
Q7S045
103
11590
Conservation
Percent
Protein Identity:
100
29.7
93.7
79
N.A.
71.5
38.5
N.A.
N.A.
39.1
37.2
37.3
N.A.
N.A.
N.A.
28.5
31
Protein Similarity:
100
48.3
95.2
86.9
N.A.
85.4
56.6
N.A.
N.A.
57.9
55.1
55.5
N.A.
N.A.
N.A.
44.2
52
P-Site Identity:
100
46.6
100
100
N.A.
100
46.6
N.A.
N.A.
46.6
53.3
46.6
N.A.
N.A.
N.A.
40
20
P-Site Similarity:
100
66.6
100
100
N.A.
100
86.6
N.A.
N.A.
80
80
80
N.A.
N.A.
N.A.
73.3
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.5
23.6
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
32.2
36
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
0
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
8
0
0
24
0
0
0
31
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
8
8
0
0
0
0
0
% D
% Glu:
0
77
0
0
0
0
0
8
8
0
77
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
54
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
8
0
31
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
31
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
39
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
39
0
54
0
0
0
31
47
0
85
0
70
0
% K
% Leu:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% L
% Met:
0
0
8
0
0
0
39
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
39
0
31
0
0
0
0
0
0
0
8
8
0
% R
% Ser:
85
0
0
0
0
39
0
62
8
0
0
0
8
0
0
% S
% Thr:
0
0
0
0
0
39
0
0
0
0
0
0
8
0
0
% T
% Val:
0
0
0
0
0
0
0
8
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
85
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
31
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _