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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGB4
All Species:
9.09
Human Site:
Y108
Identified Species:
16.67
UniProt:
Q8WW32
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.58
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WW32
NP_660206
186
22405
Y108
L
L
F
C
Q
D
H
Y
A
Q
L
K
R
E
N
Chimpanzee
Pan troglodytes
Q9N1Q7
215
24747
C135
P
L
A
F
F
L
F
C
S
E
Y
R
P
K
I
Rhesus Macaque
Macaca mulatta
XP_001107984
191
23044
Y110
L
L
F
C
Q
D
H
Y
A
Q
L
K
R
E
N
Dog
Lupus familis
XP_851529
191
22584
Y108
L
I
F
C
Q
D
H
Y
A
Q
L
K
R
E
N
Cat
Felis silvestris
Mouse
Mus musculus
Q6P8W9
181
21585
S104
P
S
S
F
L
L
F
S
R
D
H
Y
A
M
L
Rat
Rattus norvegicus
P52925
210
24140
R110
F
L
F
C
S
E
H
R
P
K
I
K
S
E
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P26584
207
23809
R110
F
L
F
C
S
E
H
R
P
K
I
K
N
D
H
Frog
Xenopus laevis
NP_001079576
212
24227
R111
F
I
F
C
S
E
H
R
P
Q
I
K
S
E
T
Zebra Danio
Brachydanio rerio
NP_001017769
198
22534
R109
F
L
F
C
A
E
Q
R
P
I
I
K
A
Q
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09390
235
27301
R150
F
F
Y
S
Q
D
K
R
P
E
I
Q
A
G
H
Sea Urchin
Strong. purpuratus
P40644
200
22815
R115
F
I
F
S
G
E
N
R
A
A
I
K
S
V
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P11633
99
11557
K22
K
R
T
T
R
R
K
K
D
P
N
A
P
K
R
Red Bread Mold
Neurospora crassa
Q7S045
103
11590
P26
A
K
K
D
P
N
A
P
K
R
G
L
S
A
Y
Conservation
Percent
Protein Identity:
100
29.7
93.7
79
N.A.
71.5
38.5
N.A.
N.A.
39.1
37.2
37.3
N.A.
N.A.
N.A.
28.5
31
Protein Similarity:
100
48.3
95.2
86.9
N.A.
85.4
56.6
N.A.
N.A.
57.9
55.1
55.5
N.A.
N.A.
N.A.
44.2
52
P-Site Identity:
100
6.6
100
93.3
N.A.
0
40
N.A.
N.A.
33.3
40
33.3
N.A.
N.A.
N.A.
13.3
20
P-Site Similarity:
100
33.3
100
100
N.A.
0
66.6
N.A.
N.A.
66.6
60
53.3
N.A.
N.A.
N.A.
46.6
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.5
23.6
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
32.2
36
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
0
8
0
8
0
31
8
0
8
24
8
0
% A
% Cys:
0
0
0
54
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
31
0
0
8
8
0
0
0
8
0
% D
% Glu:
0
0
0
0
0
39
0
0
0
16
0
0
0
39
0
% E
% Phe:
47
8
62
16
8
0
16
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
8
0
0
0
0
0
8
0
0
8
0
% G
% His:
0
0
0
0
0
0
47
0
0
0
8
0
0
0
31
% H
% Ile:
0
24
0
0
0
0
0
0
0
8
47
0
0
0
8
% I
% Lys:
8
8
8
0
0
0
16
8
8
16
0
62
0
16
0
% K
% Leu:
24
47
0
0
8
16
0
0
0
0
24
8
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
8
8
0
0
0
8
0
8
0
31
% N
% Pro:
16
0
0
0
8
0
0
8
39
8
0
0
16
0
0
% P
% Gln:
0
0
0
0
31
0
8
0
0
31
0
8
0
8
0
% Q
% Arg:
0
8
0
0
8
8
0
47
8
8
0
8
24
0
8
% R
% Ser:
0
8
8
16
24
0
0
8
8
0
0
0
31
0
0
% S
% Thr:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
8
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
24
0
0
8
8
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _