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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGB4
All Species:
14.85
Human Site:
Y142
Identified Species:
27.22
UniProt:
Q8WW32
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WW32
NP_660206
186
22405
Y142
T
D
L
E
K
H
P
Y
E
Q
R
V
A
L
L
Chimpanzee
Pan troglodytes
Q9N1Q7
215
24747
D169
W
N
N
T
A
A
S
D
K
Q
F
Y
E
K
K
Rhesus Macaque
Macaca mulatta
XP_001107984
191
23044
Y144
T
D
L
E
K
H
P
Y
E
Q
R
A
A
L
L
Dog
Lupus familis
XP_851529
191
22584
Y142
S
G
A
E
K
Q
P
Y
E
Q
R
A
A
V
L
Cat
Felis silvestris
Mouse
Mus musculus
Q6P8W9
181
21585
E138
W
S
T
T
D
E
A
E
K
K
P
Y
E
Q
K
Rat
Rattus norvegicus
P52925
210
24140
Y144
S
A
K
D
K
Q
P
Y
E
Q
K
A
A
K
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P26584
207
23809
Y144
L
A
K
D
K
Q
P
Y
E
Q
K
A
A
K
L
Frog
Xenopus laevis
NP_001079576
212
24227
H145
T
P
K
D
K
L
P
H
E
Q
K
A
A
K
L
Zebra Danio
Brachydanio rerio
NP_001017769
198
22534
F143
S
D
S
E
K
Q
P
F
L
S
N
A
D
K
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09390
235
27301
Y184
P
Q
E
T
K
D
M
Y
E
Q
K
A
Q
A
D
Sea Urchin
Strong. purpuratus
P40644
200
22815
F149
T
A
G
E
K
I
P
F
D
K
G
A
A
K
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P11633
99
11557
Q56
N
P
D
V
T
F
G
Q
V
G
R
I
L
G
E
Red Bread Mold
Neurospora crassa
Q7S045
103
11590
L60
F
G
Q
V
G
K
I
L
G
E
R
W
K
A
L
Conservation
Percent
Protein Identity:
100
29.7
93.7
79
N.A.
71.5
38.5
N.A.
N.A.
39.1
37.2
37.3
N.A.
N.A.
N.A.
28.5
31
Protein Similarity:
100
48.3
95.2
86.9
N.A.
85.4
56.6
N.A.
N.A.
57.9
55.1
55.5
N.A.
N.A.
N.A.
44.2
52
P-Site Identity:
100
6.6
93.3
60
N.A.
0
46.6
N.A.
N.A.
46.6
46.6
33.3
N.A.
N.A.
N.A.
26.6
33.3
P-Site Similarity:
100
20
93.3
73.3
N.A.
13.3
66.6
N.A.
N.A.
60
66.6
46.6
N.A.
N.A.
N.A.
33.3
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.5
23.6
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
32.2
36
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
24
8
0
8
8
8
0
0
0
0
62
54
16
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
24
8
24
8
8
0
8
8
0
0
0
8
0
16
% D
% Glu:
0
0
8
39
0
8
0
8
54
8
0
0
16
0
8
% E
% Phe:
8
0
0
0
0
8
0
16
0
0
8
0
0
0
0
% F
% Gly:
0
16
8
0
8
0
8
0
8
8
8
0
0
8
0
% G
% His:
0
0
0
0
0
16
0
8
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
8
0
0
0
0
8
0
0
0
% I
% Lys:
0
0
24
0
70
8
0
0
16
16
31
0
8
47
16
% K
% Leu:
8
0
16
0
0
8
0
8
8
0
0
0
8
16
62
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
8
8
8
0
0
0
0
0
0
0
8
0
0
0
0
% N
% Pro:
8
16
0
0
0
0
62
0
0
0
8
0
0
0
0
% P
% Gln:
0
8
8
0
0
31
0
8
0
62
0
0
8
8
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
39
0
0
0
0
% R
% Ser:
24
8
8
0
0
0
8
0
0
8
0
0
0
0
0
% S
% Thr:
31
0
8
24
8
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
16
0
0
0
0
8
0
0
8
0
8
0
% V
% Trp:
16
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
47
0
0
0
16
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _