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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGB4 All Species: 28.18
Human Site: Y16 Identified Species: 51.67
UniProt: Q8WW32 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8WW32 NP_660206 186 22405 Y16 P K A N V S S Y V H F L L N Y
Chimpanzee Pan troglodytes Q9N1Q7 215 24747 H45 K K R I L E S H N N T L V D P
Rhesus Macaque Macaca mulatta XP_001107984 191 23044 Y18 P K A N V S S Y I H F L L N Y
Dog Lupus familis XP_851529 191 22584 Y16 P K V N V S S Y I H F L L N Y
Cat Felis silvestris
Mouse Mus musculus Q6P8W9 181 21585 Y16 P K V N V S S Y I H F M L N F
Rat Rattus norvegicus P52925 210 24140 Y16 P R G K M S S Y A F F V Q T C
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P26584 207 23809 Y16 P R G K M S S Y A Y F V Q T C
Frog Xenopus laevis NP_001079576 212 24227 Y16 P R G K M S S Y A Y F V Q T C
Zebra Danio Brachydanio rerio NP_001017769 198 22534 Y16 P K G K M S A Y A Y F V K T C
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q09390 235 27301 Y52 V R G K T S P Y G F F V K M C
Sea Urchin Strong. purpuratus P40644 200 22815 Y18 P R G R M S A Y A Y F V Q D S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P11633 99 11557
Red Bread Mold Neurospora crassa Q7S045 103 11590
Conservation
Percent
Protein Identity: 100 29.7 93.7 79 N.A. 71.5 38.5 N.A. N.A. 39.1 37.2 37.3 N.A. N.A. N.A. 28.5 31
Protein Similarity: 100 48.3 95.2 86.9 N.A. 85.4 56.6 N.A. N.A. 57.9 55.1 55.5 N.A. N.A. N.A. 44.2 52
P-Site Identity: 100 20 93.3 86.6 N.A. 73.3 33.3 N.A. N.A. 33.3 33.3 33.3 N.A. N.A. N.A. 20 26.6
P-Site Similarity: 100 53.3 100 93.3 N.A. 93.3 53.3 N.A. N.A. 60 60 60 N.A. N.A. N.A. 33.3 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.5 23.6
Protein Similarity: N.A. N.A. N.A. N.A. 32.2 36
P-Site Identity: N.A. N.A. N.A. N.A. 0 0
P-Site Similarity: N.A. N.A. N.A. N.A. 0 0
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 16 0 0 0 16 0 39 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 39 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 16 0 % D
% Glu: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 16 77 0 0 0 8 % F
% Gly: 0 0 47 0 0 0 0 0 8 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 8 0 31 0 0 0 0 0 % H
% Ile: 0 0 0 8 0 0 0 0 24 0 0 0 0 0 0 % I
% Lys: 8 47 0 39 0 0 0 0 0 0 0 0 16 0 0 % K
% Leu: 0 0 0 0 8 0 0 0 0 0 0 31 31 0 0 % L
% Met: 0 0 0 0 39 0 0 0 0 0 0 8 0 8 0 % M
% Asn: 0 0 0 31 0 0 0 0 8 8 0 0 0 31 0 % N
% Pro: 70 0 0 0 0 0 8 0 0 0 0 0 0 0 8 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 31 0 0 % Q
% Arg: 0 39 8 8 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 77 62 0 0 0 0 0 0 0 8 % S
% Thr: 0 0 0 0 8 0 0 0 0 0 8 0 0 31 0 % T
% Val: 8 0 16 0 31 0 0 0 8 0 0 47 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 77 0 31 0 0 0 0 24 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _