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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGB4
All Species:
0.91
Human Site:
Y170
Identified Species:
1.67
UniProt:
Q8WW32
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WW32
NP_660206
186
22405
Y170
Q
C
N
A
R
K
K
Y
R
M
S
A
R
N
R
Chimpanzee
Pan troglodytes
Q9N1Q7
215
24747
P197
A
C
R
A
K
G
K
P
N
S
A
T
K
R
V
Rhesus Macaque
Macaca mulatta
XP_001107984
191
23044
R172
Q
R
K
Q
C
N
A
R
K
K
Y
R
M
S
A
Dog
Lupus familis
XP_851529
191
22584
L170
Q
R
N
T
R
K
G
L
Q
G
S
P
K
N
E
Cat
Felis silvestris
Mouse
Mus musculus
Q6P8W9
181
21585
G166
A
Y
R
N
Q
C
Q
G
R
K
G
N
F
L
E
Rat
Rattus norvegicus
P52925
210
24140
K172
K
G
K
S
E
V
G
K
K
G
P
G
R
P
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P26584
207
23809
K172
K
S
K
S
D
A
G
K
K
G
P
G
R
P
A
Frog
Xenopus laevis
NP_001079576
212
24227
K173
K
G
K
S
D
V
G
K
K
V
P
G
R
A
T
Zebra Danio
Brachydanio rerio
NP_001017769
198
22534
S171
K
G
S
G
G
S
S
S
A
K
S
E
P
K
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09390
235
27301
M212
E
M
Q
K
M
S
G
M
D
H
Y
D
D
D
N
Sea Urchin
Strong. purpuratus
P40644
200
22815
Q177
K
A
K
P
M
K
R
Q
V
K
E
S
S
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P11633
99
11557
K84
E
S
K
A
Q
A
D
K
K
R
Y
E
S
E
K
Red Bread Mold
Neurospora crassa
Q7S045
103
11590
D88
A
D
K
K
R
Y
E
D
E
K
Q
A
Y
N
A
Conservation
Percent
Protein Identity:
100
29.7
93.7
79
N.A.
71.5
38.5
N.A.
N.A.
39.1
37.2
37.3
N.A.
N.A.
N.A.
28.5
31
Protein Similarity:
100
48.3
95.2
86.9
N.A.
85.4
56.6
N.A.
N.A.
57.9
55.1
55.5
N.A.
N.A.
N.A.
44.2
52
P-Site Identity:
100
20
6.6
40
N.A.
6.6
6.6
N.A.
N.A.
6.6
6.6
6.6
N.A.
N.A.
N.A.
0
6.6
P-Site Similarity:
100
40
20
53.3
N.A.
20
26.6
N.A.
N.A.
26.6
33.3
20
N.A.
N.A.
N.A.
13.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.5
23.6
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
32.2
36
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
20
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
24
8
0
24
0
16
8
0
8
0
8
16
0
8
24
% A
% Cys:
0
16
0
0
8
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
16
0
8
8
8
0
0
8
8
8
8
% D
% Glu:
16
0
0
0
8
0
8
0
8
0
8
16
0
8
16
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% F
% Gly:
0
24
0
8
8
8
39
8
0
24
8
24
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
39
0
54
16
8
24
16
31
39
39
0
0
16
8
8
% K
% Leu:
0
0
0
0
0
0
0
8
0
0
0
0
0
8
0
% L
% Met:
0
8
0
0
16
0
0
8
0
8
0
0
8
0
0
% M
% Asn:
0
0
16
8
0
8
0
0
8
0
0
8
0
24
8
% N
% Pro:
0
0
0
8
0
0
0
8
0
0
24
8
8
16
0
% P
% Gln:
24
0
8
8
16
0
8
8
8
0
8
0
0
0
0
% Q
% Arg:
0
16
16
0
24
0
8
8
16
8
0
8
31
8
8
% R
% Ser:
0
16
8
24
0
16
8
8
0
8
24
8
16
16
8
% S
% Thr:
0
0
0
8
0
0
0
0
0
0
0
8
0
0
16
% T
% Val:
0
0
0
0
0
16
0
0
8
8
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
8
0
8
0
0
24
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _