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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGB4 All Species: 11.52
Human Site: Y23 Identified Species: 21.11
UniProt: Q8WW32 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8WW32 NP_660206 186 22405 Y23 Y V H F L L N Y R N K F K E Q
Chimpanzee Pan troglodytes Q9N1Q7 215 24747 P52 H N N T L V D P C E E H K K K
Rhesus Macaque Macaca mulatta XP_001107984 191 23044 Y25 Y I H F L L N Y R N K F K E Q
Dog Lupus familis XP_851529 191 22584 Y23 Y I H F L L N Y R N K F K E Q
Cat Felis silvestris
Mouse Mus musculus Q6P8W9 181 21585 F23 Y I H F M L N F R N K F K E Q
Rat Rattus norvegicus P52925 210 24140 C23 Y A F F V Q T C R E E H K K K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P26584 207 23809 C23 Y A Y F V Q T C R E E H K K K
Frog Xenopus laevis NP_001079576 212 24227 C23 Y A Y F V Q T C R E E H K K K
Zebra Danio Brachydanio rerio NP_001017769 198 22534 C23 Y A Y F V K T C R E E H N K K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q09390 235 27301 C59 Y G F F V K M C Y E E H K K K
Sea Urchin Strong. purpuratus P40644 200 22815 S25 Y A Y F V Q D S R A E H G K N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P11633 99 11557
Red Bread Mold Neurospora crassa Q7S045 103 11590
Conservation
Percent
Protein Identity: 100 29.7 93.7 79 N.A. 71.5 38.5 N.A. N.A. 39.1 37.2 37.3 N.A. N.A. N.A. 28.5 31
Protein Similarity: 100 48.3 95.2 86.9 N.A. 85.4 56.6 N.A. N.A. 57.9 55.1 55.5 N.A. N.A. N.A. 44.2 52
P-Site Identity: 100 13.3 93.3 93.3 N.A. 80 26.6 N.A. N.A. 26.6 26.6 20 N.A. N.A. N.A. 20 20
P-Site Similarity: 100 60 100 100 N.A. 100 53.3 N.A. N.A. 60 60 53.3 N.A. N.A. N.A. 46.6 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.5 23.6
Protein Similarity: N.A. N.A. N.A. N.A. 32.2 36
P-Site Identity: N.A. N.A. N.A. N.A. 0 0
P-Site Similarity: N.A. N.A. N.A. N.A. 0 0
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 39 0 0 0 0 0 0 0 8 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 39 8 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 16 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 47 54 0 0 31 0 % E
% Phe: 0 0 16 77 0 0 0 8 0 0 0 31 0 0 0 % F
% Gly: 0 8 0 0 0 0 0 0 0 0 0 0 8 0 0 % G
% His: 8 0 31 0 0 0 0 0 0 0 0 54 0 0 0 % H
% Ile: 0 24 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 16 0 0 0 0 31 0 70 54 47 % K
% Leu: 0 0 0 0 31 31 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 8 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 8 0 0 0 31 0 0 31 0 0 8 0 8 % N
% Pro: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 31 0 0 0 0 0 0 0 0 31 % Q
% Arg: 0 0 0 0 0 0 0 0 70 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 8 0 0 31 0 0 0 0 0 0 0 0 % T
% Val: 0 8 0 0 47 8 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 77 0 31 0 0 0 0 24 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _