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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APH1B
All Species:
30.91
Human Site:
S152
Identified Species:
56.67
UniProt:
Q8WW43
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WW43
NP_112591.2
257
28460
S152
T
V
G
I
H
G
D
S
P
Q
F
F
L
Y
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001105067
257
28566
S152
T
V
G
I
H
G
D
S
P
Q
F
F
L
Y
S
Dog
Lupus familis
XP_544714
346
38112
S241
T
V
G
I
H
G
D
S
P
Q
F
F
L
N
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8C7N7
257
28685
S152
T
V
G
I
H
G
D
S
P
Q
F
F
L
N
S
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514807
225
24964
H138
T
L
A
I
V
L
L
H
I
F
W
G
I
V
F
Chicken
Gallus gallus
XP_001233302
256
28091
S153
T
V
G
I
H
G
D
S
Q
L
Y
F
L
T
S
Frog
Xenopus laevis
NP_001089056
247
26905
S153
T
V
G
V
H
G
D
S
Q
Y
Y
F
L
T
S
Zebra Danio
Brachydanio rerio
Q8JHE9
258
28628
S153
T
V
G
I
H
G
E
S
Q
H
Y
F
I
S
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VQG2
238
26419
T143
T
M
G
L
K
G
G
T
E
L
F
F
V
T
S
Honey Bee
Apis mellifera
XP_392345
240
26608
T143
T
M
G
L
R
Q
G
T
E
Y
F
F
V
I
S
Nematode Worm
Caenorhab. elegans
O45876
308
33529
L154
T
I
G
L
P
N
A
L
K
T
G
E
I
D
T
Sea Urchin
Strong. purpuratus
XP_783542
260
29305
P159
T
V
G
I
H
G
D
P
H
D
F
L
I
T
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8L9G7
250
27517
S152
T
F
Y
V
E
R
C
S
K
V
P
F
F
L
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
95.7
58
N.A.
84
N.A.
N.A.
58.7
54.8
53.3
64.3
N.A.
43.9
43.9
25
40.7
Protein Similarity:
100
N.A.
98
63.5
N.A.
91.4
N.A.
N.A.
70.4
73.1
73.9
79.8
N.A.
61
62.6
44.8
60
P-Site Identity:
100
N.A.
100
93.3
N.A.
93.3
N.A.
N.A.
13.3
73.3
66.6
60
N.A.
40
33.3
13.3
60
P-Site Similarity:
100
N.A.
100
93.3
N.A.
93.3
N.A.
N.A.
33.3
80
80
80
N.A.
66.6
60
40
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.4
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
54
0
0
8
0
0
0
8
0
% D
% Glu:
0
0
0
0
8
0
8
0
16
0
0
8
0
0
0
% E
% Phe:
0
8
0
0
0
0
0
0
0
8
54
77
8
0
8
% F
% Gly:
0
0
85
0
0
70
16
0
0
0
8
8
0
0
0
% G
% His:
0
0
0
0
62
0
0
8
8
8
0
0
0
0
0
% H
% Ile:
0
8
0
62
0
0
0
0
8
0
0
0
31
8
8
% I
% Lys:
0
0
0
0
8
0
0
0
16
0
0
0
0
0
0
% K
% Leu:
0
8
0
24
0
8
8
8
0
16
0
8
47
8
0
% L
% Met:
0
16
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
8
0
0
0
0
0
0
0
16
0
% N
% Pro:
0
0
0
0
8
0
0
8
31
0
8
0
0
0
0
% P
% Gln:
0
0
0
0
0
8
0
0
24
31
0
0
0
0
0
% Q
% Arg:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
62
0
0
0
0
0
8
77
% S
% Thr:
100
0
0
0
0
0
0
16
0
8
0
0
0
31
8
% T
% Val:
0
62
0
16
8
0
0
0
0
8
0
0
16
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
0
16
24
0
0
16
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _