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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APH1B
All Species:
43.94
Human Site:
T145
Identified Species:
80.56
UniProt:
Q8WW43
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WW43
NP_112591.2
257
28460
T145
S
D
S
L
G
P
G
T
V
G
I
H
G
D
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001105067
257
28566
T145
S
D
S
L
G
P
G
T
V
G
I
H
G
D
S
Dog
Lupus familis
XP_544714
346
38112
T234
S
D
S
L
G
P
G
T
V
G
I
H
G
D
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8C7N7
257
28685
T145
S
N
S
L
G
P
G
T
V
G
I
H
G
D
S
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514807
225
24964
T131
F
L
S
S
A
F
M
T
L
A
I
V
L
L
H
Chicken
Gallus gallus
XP_001233302
256
28091
T146
A
D
A
L
G
P
G
T
V
G
I
H
G
D
S
Frog
Xenopus laevis
NP_001089056
247
26905
T146
A
D
A
I
G
P
G
T
V
G
V
H
G
D
S
Zebra Danio
Brachydanio rerio
Q8JHE9
258
28628
T146
S
D
S
L
G
P
G
T
V
G
I
H
G
E
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VQG2
238
26419
T136
A
D
M
S
G
P
G
T
M
G
L
K
G
G
T
Honey Bee
Apis mellifera
XP_392345
240
26608
T136
A
D
A
V
G
P
G
T
M
G
L
R
Q
G
T
Nematode Worm
Caenorhab. elegans
O45876
308
33529
T147
A
I
F
S
G
P
G
T
I
G
L
P
N
A
L
Sea Urchin
Strong. purpuratus
XP_783542
260
29305
T152
A
D
S
K
G
P
G
T
V
G
I
H
G
D
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8L9G7
250
27517
T145
T
P
A
F
G
P
A
T
F
Y
V
E
R
C
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
95.7
58
N.A.
84
N.A.
N.A.
58.7
54.8
53.3
64.3
N.A.
43.9
43.9
25
40.7
Protein Similarity:
100
N.A.
98
63.5
N.A.
91.4
N.A.
N.A.
70.4
73.1
73.9
79.8
N.A.
61
62.6
44.8
60
P-Site Identity:
100
N.A.
100
100
N.A.
93.3
N.A.
N.A.
20
86.6
73.3
93.3
N.A.
46.6
40
33.3
80
P-Site Similarity:
100
N.A.
100
100
N.A.
100
N.A.
N.A.
26.6
100
100
100
N.A.
73.3
80
53.3
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.4
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
47
0
31
0
8
0
8
0
0
8
0
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
70
0
0
0
0
0
0
0
0
0
0
0
54
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
8
0
8
0
% E
% Phe:
8
0
8
8
0
8
0
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
93
0
85
0
0
85
0
0
70
16
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
62
0
0
8
% H
% Ile:
0
8
0
8
0
0
0
0
8
0
62
0
0
0
0
% I
% Lys:
0
0
0
8
0
0
0
0
0
0
0
8
0
0
0
% K
% Leu:
0
8
0
47
0
0
0
0
8
0
24
0
8
8
8
% L
% Met:
0
0
8
0
0
0
8
0
16
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
0
% N
% Pro:
0
8
0
0
0
93
0
0
0
0
0
8
0
0
8
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
8
8
0
0
% R
% Ser:
39
0
54
24
0
0
0
0
0
0
0
0
0
0
62
% S
% Thr:
8
0
0
0
0
0
0
100
0
0
0
0
0
0
16
% T
% Val:
0
0
0
8
0
0
0
0
62
0
16
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _