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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APH1B
All Species:
9.09
Human Site:
Y252
Identified Species:
16.67
UniProt:
Q8WW43
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WW43
NP_112591.2
257
28460
Y252
Q
D
K
N
F
L
L
Y
N
Q
R
S
R
_
_
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001105067
257
28566
Y252
Q
D
K
D
F
L
L
Y
N
Q
R
S
R
_
_
Dog
Lupus familis
XP_544714
346
38112
F341
Q
D
K
D
F
L
L
F
N
Q
R
S
R
_
_
Cat
Felis silvestris
Mouse
Mus musculus
Q8C7N7
257
28685
Y252
Q
D
K
D
F
L
L
Y
N
Q
R
S
R
_
_
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514807
225
24964
Chicken
Gallus gallus
XP_001233302
256
28091
A250
L
L
C
A
Q
S
E
A
S
P
Q
P
A
S
_
Frog
Xenopus laevis
NP_001089056
247
26905
R240
G
G
N
Y
R
N
I
R
K
C
L
A
C
A
R
Zebra Danio
Brachydanio rerio
Q8JHE9
258
28628
A253
K
D
K
D
F
L
L
A
N
H
R
P
R
_
_
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VQG2
238
26419
F231
A
G
G
T
S
R
S
F
R
K
F
I
T
C
Q
Honey Bee
Apis mellifera
XP_392345
240
26608
R227
A
F
K
V
A
G
G
R
P
Q
S
I
R
P
Q
Nematode Worm
Caenorhab. elegans
O45876
308
33529
L272
S
I
T
D
A
V
T
L
K
Q
V
R
T
L
I
Sea Urchin
Strong. purpuratus
XP_783542
260
29305
L253
G
I
K
Q
A
F
S
L
N
R
S
R
Y
A
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8L9G7
250
27517
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
95.7
58
N.A.
84
N.A.
N.A.
58.7
54.8
53.3
64.3
N.A.
43.9
43.9
25
40.7
Protein Similarity:
100
N.A.
98
63.5
N.A.
91.4
N.A.
N.A.
70.4
73.1
73.9
79.8
N.A.
61
62.6
44.8
60
P-Site Identity:
100
N.A.
92.3
84.6
N.A.
92.3
N.A.
N.A.
0
0
0
61.5
N.A.
0
20
6.6
13.3
P-Site Similarity:
100
N.A.
100
100
N.A.
100
N.A.
N.A.
0
14.2
13.3
76.9
N.A.
13.3
20
26.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.4
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
0
8
24
0
0
16
0
0
0
8
8
16
0
% A
% Cys:
0
0
8
0
0
0
0
0
0
8
0
0
8
8
0
% C
% Asp:
0
39
0
39
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% E
% Phe:
0
8
0
0
39
8
0
16
0
0
8
0
0
0
0
% F
% Gly:
16
16
8
0
0
8
8
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
16
0
0
0
0
8
0
0
0
0
16
0
0
8
% I
% Lys:
8
0
54
0
0
0
0
0
16
8
0
0
0
0
0
% K
% Leu:
8
8
0
0
0
39
39
16
0
0
8
0
0
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
8
0
8
0
0
47
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
8
8
0
16
0
8
0
% P
% Gln:
31
0
0
8
8
0
0
0
0
47
8
0
0
0
16
% Q
% Arg:
0
0
0
0
8
8
0
16
8
8
39
16
47
0
8
% R
% Ser:
8
0
0
0
8
8
16
0
8
0
16
31
0
8
0
% S
% Thr:
0
0
8
8
0
0
8
0
0
0
0
0
16
0
0
% T
% Val:
0
0
0
8
0
8
0
0
0
0
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
24
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
39
47
% _