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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HPSE2
All Species:
9.39
Human Site:
S297
Identified Species:
22.96
UniProt:
Q8WWQ2
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WWQ2
NP_068600.3
592
66596
S297
L
Q
P
I
R
I
Y
S
R
A
S
L
Y
G
P
Chimpanzee
Pan troglodytes
XP_517183
543
61209
N260
L
R
K
S
T
F
K
N
A
K
L
Y
G
P
D
Rhesus Macaque
Macaca mulatta
XP_001104975
545
61334
N262
L
R
K
S
T
F
K
N
A
K
L
Y
G
P
D
Dog
Lupus familis
XP_850311
592
66752
S297
L
Q
P
I
R
I
Y
S
R
A
S
L
Y
G
P
Cat
Felis silvestris
Mouse
Mus musculus
Q6YGZ1
535
60032
D259
N
A
K
L
Y
G
P
D
I
G
Q
P
R
G
K
Rat
Rattus norvegicus
Q71RP1
536
60461
P259
Q
N
A
K
L
Y
G
P
D
I
G
Q
P
R
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90YK5
523
58368
H257
Q
P
R
K
H
T
Q
H
L
L
R
S
F
M
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_691045
577
65466
S283
L
Q
S
V
R
F
Y
S
R
A
N
L
Y
G
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_791694
477
53110
S211
G
N
A
T
N
I
T
S
F
H
F
Y
Y
A
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FF10
543
60232
H270
S
V
V
D
V
V
T
H
H
I
Y
N
L
G
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
43.2
43.4
98.8
N.A.
43.5
43.2
N.A.
N.A.
40.7
N.A.
73.3
N.A.
N.A.
N.A.
N.A.
26.5
Protein Similarity:
100
58.7
59.7
98.9
N.A.
58.2
59.4
N.A.
N.A.
53.7
N.A.
83.6
N.A.
N.A.
N.A.
N.A.
40.2
P-Site Identity:
100
6.6
6.6
100
N.A.
6.6
0
N.A.
N.A.
0
N.A.
73.3
N.A.
N.A.
N.A.
N.A.
20
P-Site Similarity:
100
20
20
100
N.A.
13.3
0
N.A.
N.A.
6.6
N.A.
86.6
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
24.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
20
0
0
0
0
0
20
30
0
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
10
0
0
0
10
10
0
0
0
0
0
20
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
30
0
0
10
0
10
0
10
0
0
% F
% Gly:
10
0
0
0
0
10
10
0
0
10
10
0
20
50
10
% G
% His:
0
0
0
0
10
0
0
20
10
10
0
0
0
0
0
% H
% Ile:
0
0
0
20
0
30
0
0
10
20
0
0
0
0
0
% I
% Lys:
0
0
30
20
0
0
20
0
0
20
0
0
0
0
20
% K
% Leu:
50
0
0
10
10
0
0
0
10
10
20
30
10
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% M
% Asn:
10
20
0
0
10
0
0
20
0
0
10
10
0
0
0
% N
% Pro:
0
10
20
0
0
0
10
10
0
0
0
10
10
20
30
% P
% Gln:
20
30
0
0
0
0
10
0
0
0
10
10
0
0
0
% Q
% Arg:
0
20
10
0
30
0
0
0
30
0
10
0
10
10
0
% R
% Ser:
10
0
10
20
0
0
0
40
0
0
20
10
0
0
20
% S
% Thr:
0
0
0
10
20
10
20
0
0
0
0
0
0
0
0
% T
% Val:
0
10
10
10
10
10
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
10
10
30
0
0
0
10
30
40
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _