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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF31
All Species:
25.15
Human Site:
S446
Identified Species:
36.89
UniProt:
Q8WWY3
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WWY3
NP_056444.3
499
55456
S446
S
T
I
R
D
R
S
S
G
T
A
S
S
V
A
Chimpanzee
Pan troglodytes
XP_001174758
364
40747
K321
G
K
V
G
Y
E
L
K
D
E
I
E
R
K
F
Rhesus Macaque
Macaca mulatta
XP_001116111
441
49083
P398
A
S
S
V
A
F
T
P
L
Q
G
L
E
I
V
Dog
Lupus familis
XP_850917
499
55424
S446
S
T
I
R
D
R
S
S
G
T
A
S
S
V
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8CCF0
499
55383
S446
S
T
I
R
D
R
S
S
G
T
A
S
S
V
A
Rat
Rattus norvegicus
NP_001099689
499
55397
S446
S
T
I
R
D
R
S
S
G
T
A
S
S
V
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519734
395
43621
R352
V
N
E
A
T
K
A
R
I
S
K
T
L
Q
V
Chicken
Gallus gallus
Frog
Xenopus laevis
Q5U5C5
498
55545
S445
S
T
V
R
D
R
S
S
G
T
A
S
S
V
A
Zebra Danio
Brachydanio rerio
Q7SXM7
508
56455
S457
S
T
V
R
D
R
S
S
G
T
S
S
S
V
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_648756
501
55526
G454
T
V
K
R
Q
I
S
G
T
A
S
S
V
A
F
Honey Bee
Apis mellifera
XP_394383
488
54294
G443
T
V
K
K
Q
V
S
G
T
A
S
S
V
A
F
Nematode Worm
Caenorhab. elegans
NP_491527
504
55599
M455
M
T
S
I
R
S
K
M
A
G
T
A
S
S
V
Sea Urchin
Strong. purpuratus
XP_793603
512
56872
L444
G
M
E
G
G
R
Q
L
H
R
Q
Q
M
H
G
Poplar Tree
Populus trichocarpa
XP_002320218
483
52609
S437
G
S
S
S
G
A
T
S
G
L
T
S
S
L
A
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P49704
494
56284
Q434
S
R
R
S
A
G
N
Q
A
K
L
T
K
V
M
Red Bread Mold
Neurospora crassa
Q8X066
597
66063
G528
F
K
R
R
F
E
R
G
Q
I
S
I
K
E
D
Conservation
Percent
Protein Identity:
100
70.7
88.3
99.5
N.A.
99.1
99.4
N.A.
69.9
N.A.
89.3
82.2
N.A.
61.2
64.1
45.6
62.1
Protein Similarity:
100
71.5
88.3
100
N.A.
99.5
99.8
N.A.
74.1
N.A.
95.3
89.5
N.A.
78
78.3
68
78.7
P-Site Identity:
100
0
0
100
N.A.
100
100
N.A.
0
N.A.
93.3
86.6
N.A.
20
13.3
13.3
6.6
P-Site Similarity:
100
6.6
26.6
100
N.A.
100
100
N.A.
26.6
N.A.
100
100
N.A.
33.3
33.3
20
6.6
Percent
Protein Identity:
44.6
N.A.
N.A.
N.A.
25.4
21.7
Protein Similarity:
65.1
N.A.
N.A.
N.A.
50.5
41.7
P-Site Identity:
33.3
N.A.
N.A.
N.A.
13.3
6.6
P-Site Similarity:
53.3
N.A.
N.A.
N.A.
26.6
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
7
13
7
7
0
13
13
32
7
0
13
44
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
38
0
0
0
7
0
0
0
0
0
7
% D
% Glu:
0
0
13
0
0
13
0
0
0
7
0
7
7
7
0
% E
% Phe:
7
0
0
0
7
7
0
0
0
0
0
0
0
0
19
% F
% Gly:
19
0
0
13
13
7
0
19
44
7
7
0
0
0
7
% G
% His:
0
0
0
0
0
0
0
0
7
0
0
0
0
7
0
% H
% Ile:
0
0
25
7
0
7
0
0
7
7
7
7
0
7
0
% I
% Lys:
0
13
13
7
0
7
7
7
0
7
7
0
13
7
0
% K
% Leu:
0
0
0
0
0
0
7
7
7
7
7
7
7
7
0
% L
% Met:
7
7
0
0
0
0
0
7
0
0
0
0
7
0
7
% M
% Asn:
0
7
0
0
0
0
7
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
13
0
7
7
7
7
7
7
0
7
0
% Q
% Arg:
0
7
13
50
7
44
7
7
0
7
0
0
7
0
0
% R
% Ser:
44
13
19
13
0
7
50
44
0
7
25
57
50
7
0
% S
% Thr:
13
44
0
0
7
0
13
0
13
38
13
13
0
0
0
% T
% Val:
7
13
19
7
0
7
0
0
0
0
0
0
13
44
19
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _