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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCA5 All Species: 17.88
Human Site: S757 Identified Species: 39.33
UniProt: Q8WWZ7 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8WWZ7 NP_061142.2 1642 186508 S757 F K D M D K F S G L F S A L D
Chimpanzee Pan troglodytes XP_511650 1642 186524 S757 F K D M D K F S G L F S A L D
Rhesus Macaque Macaca mulatta XP_001082244 1618 183230 P759 L E R T N K F P E L Y K D L D
Dog Lupus familis XP_537573 1642 186609 A757 F K D M D K F A G L F S A L D
Cat Felis silvestris
Mouse Mus musculus Q8K448 1642 185876 S757 F K D M D K F S G L F S A L D
Rat Rattus norvegicus Q8CF82 1642 185792 S757 F K D M D K F S G L F S A L D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509469 1722 195635 S837 F K D M D K F S G L F S D L D
Chicken Gallus gallus XP_415695 1646 186355 A760 L R D M D K F A G L F S D L D
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001092716 1654 185619 P760 F E S M D T F P G L F A E L D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34358 1704 191394 K821 I I L P E A R K K E F V P L F
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84M24 1882 209045 N826 A S L P C F E N M F R E I E S
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 42.1 93 N.A. 90 90.2 N.A. 81.3 71.5 N.A. 52 N.A. N.A. N.A. 22.5 N.A.
Protein Similarity: 100 99.8 62.8 96.7 N.A. 94.8 95.1 N.A. 88 86 N.A. 70.5 N.A. N.A. N.A. 44.1 N.A.
P-Site Identity: 100 100 33.3 93.3 N.A. 100 100 N.A. 93.3 73.3 N.A. 60 N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: 100 100 53.3 100 N.A. 100 100 N.A. 93.3 86.6 N.A. 73.3 N.A. N.A. N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 26.4 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 45.4 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 0 0 10 0 19 0 0 0 10 46 0 0 % A
% Cys: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 64 0 73 0 0 0 0 0 0 0 28 0 82 % D
% Glu: 0 19 0 0 10 0 10 0 10 10 0 10 10 10 0 % E
% Phe: 64 0 0 0 0 10 82 0 0 10 82 0 0 0 10 % F
% Gly: 0 0 0 0 0 0 0 0 73 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 10 10 0 0 0 0 0 0 0 0 0 0 10 0 0 % I
% Lys: 0 55 0 0 0 73 0 10 10 0 0 10 0 0 0 % K
% Leu: 19 0 19 0 0 0 0 0 0 82 0 0 0 91 0 % L
% Met: 0 0 0 73 0 0 0 0 10 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 10 0 0 10 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 19 0 0 0 19 0 0 0 0 10 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 10 10 0 0 0 10 0 0 0 10 0 0 0 0 % R
% Ser: 0 10 10 0 0 0 0 46 0 0 0 64 0 0 10 % S
% Thr: 0 0 0 10 0 10 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _