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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCA5 All Species: 21.21
Human Site: Y168 Identified Species: 46.67
UniProt: Q8WWZ7 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8WWZ7 NP_061142.2 1642 186508 Y168 K S C E A A Q Y W S S G F T V
Chimpanzee Pan troglodytes XP_511650 1642 186524 Y168 K S C E A A Q Y W S S G F T V
Rhesus Macaque Macaca mulatta XP_001082244 1618 183230 F172 V Y C E V S V F W K E G F V A
Dog Lupus familis XP_537573 1642 186609 Y168 T S C E A A Q Y W S S G F T V
Cat Felis silvestris
Mouse Mus musculus Q8K448 1642 185876 Y168 K T C D A A Q Y W S L G F T V
Rat Rattus norvegicus Q8CF82 1642 185792 Y168 K S C D A A Q Y W S S G F T A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509469 1722 195635 Y248 K S C E A A I Y W H S G F T I
Chicken Gallus gallus XP_415695 1646 186355 I169 M R M S C E S I T Y W T S G F
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001092716 1654 185619 A166 T N Y V N C R A A N Y W Y S G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34358 1704 191394 P196 T S Y N P Y G P S S G R Y S R
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84M24 1882 209045 G187 K S I M D T N G P Y I N D L E
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 42.1 93 N.A. 90 90.2 N.A. 81.3 71.5 N.A. 52 N.A. N.A. N.A. 22.5 N.A.
Protein Similarity: 100 99.8 62.8 96.7 N.A. 94.8 95.1 N.A. 88 86 N.A. 70.5 N.A. N.A. N.A. 44.1 N.A.
P-Site Identity: 100 100 33.3 93.3 N.A. 80 86.6 N.A. 80 0 N.A. 0 N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: 100 100 46.6 93.3 N.A. 93.3 93.3 N.A. 86.6 0 N.A. 33.3 N.A. N.A. N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 26.4 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 45.4 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 55 55 0 10 10 0 0 0 0 0 19 % A
% Cys: 0 0 64 0 10 10 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 19 10 0 0 0 0 0 0 0 10 0 0 % D
% Glu: 0 0 0 46 0 10 0 0 0 0 10 0 0 0 10 % E
% Phe: 0 0 0 0 0 0 0 10 0 0 0 0 64 0 10 % F
% Gly: 0 0 0 0 0 0 10 10 0 0 10 64 0 10 10 % G
% His: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % H
% Ile: 0 0 10 0 0 0 10 10 0 0 10 0 0 0 10 % I
% Lys: 55 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 10 0 0 10 0 % L
% Met: 10 0 10 10 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 10 0 10 10 0 10 0 0 10 0 10 0 0 0 % N
% Pro: 0 0 0 0 10 0 0 10 10 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 46 0 0 0 0 0 0 0 0 % Q
% Arg: 0 10 0 0 0 0 10 0 0 0 0 10 0 0 10 % R
% Ser: 0 64 0 10 0 10 10 0 10 55 46 0 10 19 0 % S
% Thr: 28 10 0 0 0 10 0 0 10 0 0 10 0 55 0 % T
% Val: 10 0 0 10 10 0 10 0 0 0 0 0 0 10 37 % V
% Trp: 0 0 0 0 0 0 0 0 64 0 10 10 0 0 0 % W
% Tyr: 0 10 19 0 0 10 0 55 0 19 10 0 19 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _