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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTR3C
All Species:
1.21
Human Site:
S404
Identified Species:
2.96
UniProt:
Q8WXA8
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WXA8
NP_570126.2
447
50220
S404
E
T
E
P
D
G
G
S
G
W
T
K
T
Q
L
Chimpanzee
Pan troglodytes
Q5IS76
494
56903
S445
F
I
A
E
N
M
K
S
H
N
E
T
K
E
V
Rhesus Macaque
Macaca mulatta
Q866A2
502
56411
E459
E
S
E
A
V
C
S
E
W
K
F
A
A
C
V
Dog
Lupus familis
XP_849162
446
50388
D403
S
T
R
A
K
Q
E
D
E
A
Q
R
Q
H
L
Cat
Felis silvestris
Mouse
Mus musculus
P23979
487
56038
K440
S
I
R
H
F
L
E
K
R
D
E
M
R
E
V
Rat
Rattus norvegicus
P35563
483
55410
K436
S
I
R
H
S
L
E
K
R
D
E
M
R
E
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519474
387
44401
R345
L
E
R
R
E
E
C
R
D
I
S
R
D
W
L
Chicken
Gallus gallus
Q9I8C7
452
50034
F408
V
G
Y
I
A
G
V
F
R
R
H
R
T
A
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_700338
466
53299
K419
T
I
R
Q
F
L
E
K
K
D
E
S
R
E
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P17644
576
65488
N496
E
L
E
K
A
I
H
N
V
M
F
I
Q
H
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
26.5
27.2
80.3
N.A.
34.5
35.2
N.A.
32.4
27.8
N.A.
34.9
N.A.
21.8
N.A.
N.A.
N.A.
Protein Similarity:
100
43.7
43.8
87.6
N.A.
54.8
56.1
N.A.
48.7
47.7
N.A.
54.7
N.A.
39.5
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
13.3
13.3
N.A.
0
0
N.A.
6.6
13.3
N.A.
0
N.A.
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
26.6
26.6
20
N.A.
13.3
13.3
N.A.
26.6
20
N.A.
13.3
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
20
20
0
0
0
0
10
0
10
10
10
0
% A
% Cys:
0
0
0
0
0
10
10
0
0
0
0
0
0
10
0
% C
% Asp:
0
0
0
0
10
0
0
10
10
30
0
0
10
0
0
% D
% Glu:
30
10
30
10
10
10
40
10
10
0
40
0
0
40
0
% E
% Phe:
10
0
0
0
20
0
0
10
0
0
20
0
0
0
0
% F
% Gly:
0
10
0
0
0
20
10
0
10
0
0
0
0
0
0
% G
% His:
0
0
0
20
0
0
10
0
10
0
10
0
0
20
10
% H
% Ile:
0
40
0
10
0
10
0
0
0
10
0
10
0
0
10
% I
% Lys:
0
0
0
10
10
0
10
30
10
10
0
10
10
0
0
% K
% Leu:
10
10
0
0
0
30
0
0
0
0
0
0
0
0
30
% L
% Met:
0
0
0
0
0
10
0
0
0
10
0
20
0
0
0
% M
% Asn:
0
0
0
0
10
0
0
10
0
10
0
0
0
0
0
% N
% Pro:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
10
0
10
0
0
0
0
10
0
20
10
10
% Q
% Arg:
0
0
50
10
0
0
0
10
30
10
0
30
30
0
0
% R
% Ser:
30
10
0
0
10
0
10
20
0
0
10
10
0
0
0
% S
% Thr:
10
20
0
0
0
0
0
0
0
0
10
10
20
0
0
% T
% Val:
10
0
0
0
10
0
10
0
10
0
0
0
0
0
40
% V
% Trp:
0
0
0
0
0
0
0
0
10
10
0
0
0
10
0
% W
% Tyr:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _