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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ATG4A All Species: 17.58
Human Site: S192 Identified Species: 35.15
UniProt: Q8WYN0 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8WYN0 NP_443168.2 398 45378 S192 M C R V L P L S A D T A G D R
Chimpanzee Pan troglodytes XP_529098 398 45427 S192 M C R V L P L S I D T P G D R
Rhesus Macaque Macaca mulatta XP_001097251 398 45435 S192 M C R V L P L S A D T A G D R
Dog Lupus familis XP_538136 460 52068 S254 M C C V L P L S A D T I G E S
Cat Felis silvestris
Mouse Mus musculus Q8C9S8 396 45076 A193 C C V L P V G A A D P A G D F
Rat Rattus norvegicus NP_001119770 406 45887 A193 C C V L P V G A A D T A G E S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513122 528 59425 G326 C K P N F P A G A S A F P T D
Chicken Gallus gallus Q5ZIW7 380 43364 T178 S P P Q S S S T A H S S A H L
Frog Xenopus laevis Q6GPU1 397 45280 S194 M C K Y Q P Q S C S M A Q A A
Zebra Danio Brachydanio rerio Q6DG88 394 44435 V196 F D R G A C A V S E E P R E M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001198708 393 44309 S203 E E T S S E G S K T G S E R R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8S929 467 51510 T206 P E Q E Y L E T L E P F G D S
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 98.7 81.5 N.A. 91.9 91.3 N.A. 41.4 78.6 74.3 54.5 N.A. N.A. N.A. N.A. 47.2
Protein Similarity: 100 99.5 99.2 83.9 N.A. 95.7 95.5 N.A. 55.8 86.1 84.9 70.5 N.A. N.A. N.A. N.A. 64.5
P-Site Identity: 100 86.6 100 73.3 N.A. 40 40 N.A. 13.3 6.6 33.3 6.6 N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 86.6 100 80 N.A. 53.3 60 N.A. 13.3 26.6 40 26.6 N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. 22.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 42.8 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 9 0 17 17 59 0 9 42 9 9 9 % A
% Cys: 25 59 9 0 0 9 0 0 9 0 0 0 0 0 0 % C
% Asp: 0 9 0 0 0 0 0 0 0 50 0 0 0 42 9 % D
% Glu: 9 17 0 9 0 9 9 0 0 17 9 0 9 25 0 % E
% Phe: 9 0 0 0 9 0 0 0 0 0 0 17 0 0 9 % F
% Gly: 0 0 0 9 0 0 25 9 0 0 9 0 59 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 9 0 0 0 9 0 % H
% Ile: 0 0 0 0 0 0 0 0 9 0 0 9 0 0 0 % I
% Lys: 0 9 9 0 0 0 0 0 9 0 0 0 0 0 0 % K
% Leu: 0 0 0 17 34 9 34 0 9 0 0 0 0 0 9 % L
% Met: 42 0 0 0 0 0 0 0 0 0 9 0 0 0 9 % M
% Asn: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 9 9 17 0 17 50 0 0 0 0 17 17 9 0 0 % P
% Gln: 0 0 9 9 9 0 9 0 0 0 0 0 9 0 0 % Q
% Arg: 0 0 34 0 0 0 0 0 0 0 0 0 9 9 34 % R
% Ser: 9 0 0 9 17 9 9 50 9 17 9 17 0 0 25 % S
% Thr: 0 0 9 0 0 0 0 17 0 9 42 0 0 9 0 % T
% Val: 0 0 17 34 0 17 0 9 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 9 9 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _