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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ATG4A
All Species:
30.91
Human Site:
S380
Identified Species:
61.82
UniProt:
Q8WYN0
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WYN0
NP_443168.2
398
45378
S380
T
G
A
E
F
I
D
S
T
E
Q
L
E
E
F
Chimpanzee
Pan troglodytes
XP_529098
398
45427
S380
T
G
A
E
F
I
D
S
T
E
Q
L
E
E
F
Rhesus Macaque
Macaca mulatta
XP_001097251
398
45435
S380
T
G
A
E
F
I
D
S
T
E
Q
L
E
E
F
Dog
Lupus familis
XP_538136
460
52068
S442
T
G
A
E
F
I
D
S
T
E
Q
L
E
D
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8C9S8
396
45076
S377
T
G
A
E
F
I
E
S
T
E
Q
L
E
D
F
Rat
Rattus norvegicus
NP_001119770
406
45887
S388
T
G
A
E
F
I
D
S
T
E
Q
L
E
D
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513122
528
59425
R511
L
D
S
S
D
A
E
R
L
E
R
F
F
D
S
Chicken
Gallus gallus
Q5ZIW7
380
43364
S364
T
G
A
E
L
I
E
S
T
D
K
L
F
E
L
Frog
Xenopus laevis
Q6GPU1
397
45280
S381
T
G
A
E
L
I
E
S
T
D
K
L
F
D
V
Zebra Danio
Brachydanio rerio
Q6DG88
394
44435
R377
P
D
F
S
D
S
D
R
L
E
R
F
F
D
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001198708
393
44309
Y377
F
E
I
R
D
C
E
Y
P
D
E
D
F
H
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8S929
467
51510
D411
A
L
G
F
Y
C
R
D
K
D
D
F
D
D
F
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.7
81.5
N.A.
91.9
91.3
N.A.
41.4
78.6
74.3
54.5
N.A.
N.A.
N.A.
N.A.
47.2
Protein Similarity:
100
99.5
99.2
83.9
N.A.
95.7
95.5
N.A.
55.8
86.1
84.9
70.5
N.A.
N.A.
N.A.
N.A.
64.5
P-Site Identity:
100
100
100
93.3
N.A.
86.6
93.3
N.A.
6.6
60
53.3
13.3
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
33.3
80
80
26.6
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.9
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.8
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
67
0
0
9
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
17
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
17
0
0
25
0
50
9
0
34
9
9
9
59
0
% D
% Glu:
0
9
0
67
0
0
42
0
0
67
9
0
50
34
0
% E
% Phe:
9
0
9
9
50
0
0
0
0
0
0
25
42
0
59
% F
% Gly:
0
67
9
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% H
% Ile:
0
0
9
0
0
67
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
9
0
17
0
0
0
0
% K
% Leu:
9
9
0
0
17
0
0
0
17
0
0
67
0
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% N
% Pro:
9
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
50
0
0
0
0
% Q
% Arg:
0
0
0
9
0
0
9
17
0
0
17
0
0
0
0
% R
% Ser:
0
0
9
17
0
9
0
67
0
0
0
0
0
0
17
% S
% Thr:
67
0
0
0
0
0
0
0
67
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
9
0
0
9
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _