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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RAPGEF4
All Species:
22.12
Human Site:
S608
Identified Species:
40.56
UniProt:
Q8WZA2
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WZA2
NP_001093867.1
1011
115522
S608
F
L
E
E
F
Y
V
S
V
S
D
D
A
R
M
Chimpanzee
Pan troglodytes
XP_522596
881
99309
A511
P
L
P
G
S
S
C
A
I
R
V
G
D
K
V
Rhesus Macaque
Macaca mulatta
XP_001086678
1077
122312
S674
F
L
E
E
F
Y
V
S
V
S
D
D
A
R
M
Dog
Lupus familis
XP_545524
1011
115217
S608
F
L
E
E
F
Y
V
S
V
S
D
D
A
R
M
Cat
Felis silvestris
Mouse
Mus musculus
Q9EQZ6
1011
115473
S608
F
L
E
E
F
Y
V
S
V
S
D
D
A
R
M
Rat
Rattus norvegicus
Q9Z1C7
436
50098
Q66
S
E
D
A
K
A
P
Q
K
K
H
K
V
L
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514742
1011
115505
S608
F
L
E
E
F
Y
V
S
V
S
D
D
T
R
I
Chicken
Gallus gallus
XP_426579
1011
115518
S608
F
L
E
E
F
Y
V
S
V
S
D
D
T
R
M
Frog
Xenopus laevis
NP_001089076
890
102453
G520
N
T
Y
T
I
R
A
G
D
K
V
P
Y
D
I
Zebra Danio
Brachydanio rerio
XP_687578
1006
115354
M602
F
I
Q
E
F
Y
E
M
V
C
E
D
S
R
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001097202
998
112889
D595
A
E
V
E
A
D
P
D
L
N
E
E
T
S
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34578
1234
141798
H828
F
V
E
E
L
F
C
H
V
I
D
D
R
K
R
Sea Urchin
Strong. purpuratus
XP_784278
676
77986
G306
V
K
S
T
K
D
S
G
S
H
T
W
Q
V
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
44.3
90.8
97.8
N.A.
97.3
41.3
N.A.
93.9
92.1
45.4
78.6
N.A.
49
N.A.
31.6
39.6
Protein Similarity:
100
61
91.5
98.9
N.A.
98.6
42
N.A.
97.7
96.7
62.2
89.5
N.A.
67
N.A.
50
51.4
P-Site Identity:
100
6.6
100
100
N.A.
100
0
N.A.
86.6
93.3
0
46.6
N.A.
6.6
N.A.
40
0
P-Site Similarity:
100
33.3
100
100
N.A.
100
13.3
N.A.
93.3
93.3
6.6
80
N.A.
40
N.A.
60
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
8
8
8
8
8
0
0
0
0
31
0
0
% A
% Cys:
0
0
0
0
0
0
16
0
0
8
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
16
0
8
8
0
54
62
8
8
0
% D
% Glu:
0
16
54
70
0
0
8
0
0
0
16
8
0
0
0
% E
% Phe:
62
0
0
0
54
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
0
0
16
0
0
0
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
8
0
8
8
0
0
0
0
% H
% Ile:
0
8
0
0
8
0
0
0
8
8
0
0
0
0
24
% I
% Lys:
0
8
0
0
16
0
0
0
8
16
0
8
0
16
0
% K
% Leu:
0
54
0
0
8
0
0
0
8
0
0
0
0
8
24
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
39
% M
% Asn:
8
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% N
% Pro:
8
0
8
0
0
0
16
0
0
0
0
8
0
0
0
% P
% Gln:
0
0
8
0
0
0
0
8
0
0
0
0
8
0
0
% Q
% Arg:
0
0
0
0
0
8
0
0
0
8
0
0
8
54
8
% R
% Ser:
8
0
8
0
8
8
8
47
8
47
0
0
8
8
0
% S
% Thr:
0
8
0
16
0
0
0
0
0
0
8
0
24
0
0
% T
% Val:
8
8
8
0
0
0
47
0
62
0
16
0
8
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
0
0
8
0
0
54
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _