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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMPDL3A
All Species:
22.73
Human Site:
S71
Identified Species:
45.45
UniProt:
Q92484
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92484
NP_006705.1
453
51260
S71
S
S
K
G
A
N
A
S
N
P
G
P
F
G
D
Chimpanzee
Pan troglodytes
XP_518720
453
51246
S71
S
S
K
G
A
N
A
S
N
P
G
T
F
G
D
Rhesus Macaque
Macaca mulatta
XP_001108274
453
51294
S71
S
S
K
G
A
N
A
S
N
P
G
P
F
G
D
Dog
Lupus familis
XP_533485
452
51228
S70
S
S
K
G
A
N
A
S
N
P
G
P
F
G
D
Cat
Felis silvestris
Mouse
Mus musculus
P70158
445
49798
S68
S
S
K
G
A
N
A
S
N
P
G
P
F
G
D
Rat
Rattus norvegicus
Q641Z7
445
49877
S68
S
S
K
G
A
N
V
S
N
P
G
P
F
G
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516772
436
49539
N58
L
S
A
F
S
F
M
N
R
S
G
Q
P
A
S
Chicken
Gallus gallus
XP_001232192
454
51318
C60
G
P
W
G
S
Y
L
C
D
A
P
W
G
L
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001014360
441
50109
K56
H
V
T
E
D
H
T
K
V
C
F
S
S
K
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_729555
488
55653
S66
S
P
W
R
L
I
E
S
A
V
K
T
M
K
A
Honey Bee
Apis mellifera
XP_394055
470
53476
K56
N
G
V
G
G
G
R
K
T
P
G
K
F
G
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786766
452
51341
A57
C
S
E
A
I
D
P
A
Q
Y
P
L
G
N
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
95.8
82.7
N.A.
79.2
79.6
N.A.
68.2
38.3
N.A.
54.2
N.A.
27.8
32.3
N.A.
34.8
Protein Similarity:
100
99.7
97.5
90.2
N.A.
88
88
N.A.
78.3
56.8
N.A.
68.8
N.A.
46.9
51.4
N.A.
56.2
P-Site Identity:
100
93.3
100
100
N.A.
100
93.3
N.A.
13.3
6.6
N.A.
0
N.A.
13.3
40
N.A.
6.6
P-Site Similarity:
100
93.3
100
100
N.A.
100
93.3
N.A.
26.6
20
N.A.
6.6
N.A.
13.3
46.6
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
9
50
0
42
9
9
9
0
0
0
9
9
% A
% Cys:
9
0
0
0
0
0
0
9
0
9
0
0
0
0
0
% C
% Asp:
0
0
0
0
9
9
0
0
9
0
0
0
0
0
59
% D
% Glu:
0
0
9
9
0
0
9
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
9
0
9
0
0
0
0
9
0
59
0
0
% F
% Gly:
9
9
0
67
9
9
0
0
0
0
67
0
17
59
9
% G
% His:
9
0
0
0
0
9
0
0
0
0
0
0
0
0
9
% H
% Ile:
0
0
0
0
9
9
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
50
0
0
0
0
17
0
0
9
9
0
17
0
% K
% Leu:
9
0
0
0
9
0
9
0
0
0
0
9
0
9
9
% L
% Met:
0
0
0
0
0
0
9
0
0
0
0
0
9
0
0
% M
% Asn:
9
0
0
0
0
50
0
9
50
0
0
0
0
9
0
% N
% Pro:
0
17
0
0
0
0
9
0
0
59
17
42
9
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
9
0
0
9
0
0
0
% Q
% Arg:
0
0
0
9
0
0
9
0
9
0
0
0
0
0
0
% R
% Ser:
59
67
0
0
17
0
0
59
0
9
0
9
9
0
9
% S
% Thr:
0
0
9
0
0
0
9
0
9
0
0
17
0
0
0
% T
% Val:
0
9
9
0
0
0
9
0
9
9
0
0
0
0
0
% V
% Trp:
0
0
17
0
0
0
0
0
0
0
0
9
0
0
0
% W
% Tyr:
0
0
0
0
0
9
0
0
0
9
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _