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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMPDL3A
All Species:
14.55
Human Site:
Y291
Identified Species:
29.09
UniProt:
Q92484
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92484
NP_006705.1
453
51260
Y291
D
V
I
A
G
Q
F
Y
G
H
T
H
R
D
S
Chimpanzee
Pan troglodytes
XP_518720
453
51246
Y291
D
I
I
A
G
Q
F
Y
G
H
T
H
R
D
S
Rhesus Macaque
Macaca mulatta
XP_001108274
453
51294
Y291
D
V
I
A
G
Q
F
Y
G
H
T
H
R
D
S
Dog
Lupus familis
XP_533485
452
51228
Y290
D
I
I
A
G
Q
F
Y
G
H
T
H
R
D
S
Cat
Felis silvestris
Mouse
Mus musculus
P70158
445
49798
G285
R
Y
S
S
V
I
A
G
Q
F
Y
G
H
T
H
Rat
Rattus norvegicus
Q641Z7
445
49877
G285
R
Y
S
S
V
I
A
G
Q
F
Y
G
H
T
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516772
436
49539
N276
D
D
Q
G
R
P
V
N
S
L
F
V
A
P
A
Chicken
Gallus gallus
XP_001232192
454
51318
Y283
T
D
S
F
R
M
F
Y
S
D
T
G
S
P
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001014360
441
50109
R274
E
Q
L
V
K
I
F
R
N
Y
S
E
V
V
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_729555
488
55653
F285
A
P
V
I
Q
G
Q
F
F
G
H
L
H
S
D
Honey Bee
Apis mellifera
XP_394055
470
53476
F274
D
I
I
R
G
Q
F
F
G
H
W
H
T
D
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786766
452
51341
F277
N
V
I
K
G
Q
F
F
G
H
H
H
Y
D
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
95.8
82.7
N.A.
79.2
79.6
N.A.
68.2
38.3
N.A.
54.2
N.A.
27.8
32.3
N.A.
34.8
Protein Similarity:
100
99.7
97.5
90.2
N.A.
88
88
N.A.
78.3
56.8
N.A.
68.8
N.A.
46.9
51.4
N.A.
56.2
P-Site Identity:
100
93.3
100
93.3
N.A.
0
0
N.A.
6.6
20
N.A.
6.6
N.A.
0
60
N.A.
66.6
P-Site Similarity:
100
100
100
100
N.A.
6.6
6.6
N.A.
13.3
20
N.A.
33.3
N.A.
13.3
80
N.A.
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
34
0
0
17
0
0
0
0
0
9
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
50
17
0
0
0
0
0
0
0
9
0
0
0
50
9
% D
% Glu:
9
0
0
0
0
0
0
0
0
0
0
9
0
0
9
% E
% Phe:
0
0
0
9
0
0
67
25
9
17
9
0
0
0
0
% F
% Gly:
0
0
0
9
50
9
0
17
50
9
0
25
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
50
17
50
25
0
17
% H
% Ile:
0
25
50
9
0
25
0
0
0
0
0
0
0
0
9
% I
% Lys:
0
0
0
9
9
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
9
0
0
0
0
0
0
9
0
9
0
0
0
% L
% Met:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% M
% Asn:
9
0
0
0
0
0
0
9
9
0
0
0
0
0
0
% N
% Pro:
0
9
0
0
0
9
0
0
0
0
0
0
0
17
0
% P
% Gln:
0
9
9
0
9
50
9
0
17
0
0
0
0
0
0
% Q
% Arg:
17
0
0
9
17
0
0
9
0
0
0
0
34
0
0
% R
% Ser:
0
0
25
17
0
0
0
0
17
0
9
0
9
9
42
% S
% Thr:
9
0
0
0
0
0
0
0
0
0
42
0
9
17
9
% T
% Val:
0
25
9
9
17
0
9
0
0
0
0
9
9
9
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% W
% Tyr:
0
17
0
0
0
0
0
42
0
9
17
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _