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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMPDL3A
All Species:
16.97
Human Site:
Y378
Identified Species:
33.94
UniProt:
Q92484
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92484
NP_006705.1
453
51260
Y378
E
Y
I
L
T
Q
T
Y
D
I
E
D
L
Q
P
Chimpanzee
Pan troglodytes
XP_518720
453
51246
Y378
E
Y
I
L
T
Q
T
Y
N
I
E
D
L
Q
P
Rhesus Macaque
Macaca mulatta
XP_001108274
453
51294
Y378
E
Y
T
L
T
Q
T
Y
D
I
E
D
L
Q
P
Dog
Lupus familis
XP_533485
452
51228
Y377
E
Y
V
L
T
Q
T
Y
N
I
E
D
L
Q
P
Cat
Felis silvestris
Mouse
Mus musculus
P70158
445
49798
T372
W
T
L
E
Y
V
L
T
Q
A
Y
S
V
A
D
Rat
Rattus norvegicus
Q641Z7
445
49877
T372
W
T
L
E
Y
T
L
T
Q
A
Y
G
V
A
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516772
436
49539
L363
L
A
K
Q
F
A
R
L
D
S
K
Q
F
Q
K
Chicken
Gallus gallus
XP_001232192
454
51318
M370
P
D
G
S
T
H
S
M
Q
T
V
L
E
R
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001014360
441
50109
G361
A
N
L
E
Q
R
S
G
W
K
L
E
Y
I
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_729555
488
55653
Y372
E
Y
N
L
T
H
Y
Y
A
L
P
E
I
S
A
Honey Bee
Apis mellifera
XP_394055
470
53476
E361
L
E
Y
Y
N
L
Q
E
I
T
A
I
S
L
H
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786766
452
51341
P364
Y
N
I
A
D
L
S
P
V
S
L
D
Q
L
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
95.8
82.7
N.A.
79.2
79.6
N.A.
68.2
38.3
N.A.
54.2
N.A.
27.8
32.3
N.A.
34.8
Protein Similarity:
100
99.7
97.5
90.2
N.A.
88
88
N.A.
78.3
56.8
N.A.
68.8
N.A.
46.9
51.4
N.A.
56.2
P-Site Identity:
100
93.3
93.3
86.6
N.A.
0
0
N.A.
13.3
6.6
N.A.
0
N.A.
33.3
0
N.A.
13.3
P-Site Similarity:
100
100
93.3
100
N.A.
13.3
13.3
N.A.
20
20
N.A.
26.6
N.A.
53.3
0
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
0
9
0
9
0
0
9
17
9
0
0
17
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
0
0
9
0
0
0
25
0
0
42
0
0
17
% D
% Glu:
42
9
0
25
0
0
0
9
0
0
34
17
9
0
0
% E
% Phe:
0
0
0
0
9
0
0
0
0
0
0
0
9
0
0
% F
% Gly:
0
0
9
0
0
0
0
9
0
0
0
9
0
0
0
% G
% His:
0
0
0
0
0
17
0
0
0
0
0
0
0
0
9
% H
% Ile:
0
0
25
0
0
0
0
0
9
34
0
9
9
9
9
% I
% Lys:
0
0
9
0
0
0
0
0
0
9
9
0
0
0
9
% K
% Leu:
17
0
25
42
0
17
17
9
0
9
17
9
34
17
0
% L
% Met:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
9
% M
% Asn:
0
17
9
0
9
0
0
0
17
0
0
0
0
0
0
% N
% Pro:
9
0
0
0
0
0
0
9
0
0
9
0
0
0
34
% P
% Gln:
0
0
0
9
9
34
9
0
25
0
0
9
9
42
0
% Q
% Arg:
0
0
0
0
0
9
9
0
0
0
0
0
0
9
0
% R
% Ser:
0
0
0
9
0
0
25
0
0
17
0
9
9
9
0
% S
% Thr:
0
17
9
0
50
9
34
17
0
17
0
0
0
0
0
% T
% Val:
0
0
9
0
0
9
0
0
9
0
9
0
17
0
9
% V
% Trp:
17
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% W
% Tyr:
9
42
9
9
17
0
9
42
0
0
17
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _