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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMPDL3B
All Species:
11.82
Human Site:
S345
Identified Species:
23.64
UniProt:
Q92485
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92485
NP_001009568.1
455
50814
S345
V
T
Y
F
M
N
L
S
Q
A
N
A
Q
G
T
Chimpanzee
Pan troglodytes
XP_001151336
455
50854
S345
V
T
Y
F
M
N
L
S
Q
A
N
A
Q
G
M
Rhesus Macaque
Macaca mulatta
XP_001108274
453
51294
K346
Q
Y
D
P
R
D
Y
K
L
L
D
M
L
Q
Y
Dog
Lupus familis
XP_544464
468
52011
S357
V
T
Y
F
V
N
L
S
Q
A
N
A
Q
G
T
Cat
Felis silvestris
Mouse
Mus musculus
P58242
456
51581
R345
V
T
Y
F
L
N
L
R
Q
A
N
V
Q
E
T
Rat
Rattus norvegicus
Q641Z7
445
49877
K338
G
V
R
L
F
Q
Y
K
P
G
D
Y
T
L
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516772
436
49539
T323
W
Q
Y
Y
L
N
L
T
E
A
N
L
K
E
E
Chicken
Gallus gallus
XP_001232192
454
51318
L340
V
V
T
Y
Y
L
N
L
T
R
A
N
L
M
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_692822
457
52265
L346
I
I
T
Y
Y
L
N
L
T
Y
A
N
I
A
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_729555
488
55653
A354
F
W
L
D
L
P
L
A
N
R
A
N
E
P
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_505620
755
86279
D347
T
Y
F
I
N
L
D
D
L
N
K
N
K
S
T
Sea Urchin
Strong. purpuratus
XP_786766
452
51341
P345
L
D
I
S
M
D
K
P
T
W
E
L
E
Y
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
40.2
76.2
N.A.
75.6
39.3
N.A.
38
61
N.A.
54.2
N.A.
28.6
N.A.
23.8
39.3
Protein Similarity:
100
99.5
58
83.9
N.A.
86.1
58.4
N.A.
55.8
74
N.A.
71.1
N.A.
47.9
N.A.
37
58
P-Site Identity:
100
93.3
0
93.3
N.A.
73.3
0
N.A.
33.3
6.6
N.A.
0
N.A.
13.3
N.A.
6.6
6.6
P-Site Similarity:
100
93.3
13.3
100
N.A.
80
6.6
N.A.
66.6
13.3
N.A.
13.3
N.A.
33.3
N.A.
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
9
0
42
25
25
0
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
9
9
0
17
9
9
0
0
17
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
9
0
9
0
17
17
9
% E
% Phe:
9
0
9
34
9
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
9
0
0
0
0
0
0
0
0
9
0
0
0
25
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
9
9
9
9
0
0
0
0
0
0
0
0
9
0
0
% I
% Lys:
0
0
0
0
0
0
9
17
0
0
9
0
17
0
0
% K
% Leu:
9
0
9
9
25
25
50
17
17
9
0
17
17
9
9
% L
% Met:
0
0
0
0
25
0
0
0
0
0
0
9
0
9
9
% M
% Asn:
0
0
0
0
9
42
17
0
9
9
42
34
0
0
0
% N
% Pro:
0
0
0
9
0
9
0
9
9
0
0
0
0
9
0
% P
% Gln:
9
9
0
0
0
9
0
0
34
0
0
0
34
9
0
% Q
% Arg:
0
0
9
0
9
0
0
9
0
17
0
0
0
0
17
% R
% Ser:
0
0
0
9
0
0
0
25
0
0
0
0
0
9
0
% S
% Thr:
9
34
17
0
0
0
0
9
25
0
0
0
9
0
42
% T
% Val:
42
17
0
0
9
0
0
0
0
0
0
9
0
0
9
% V
% Trp:
9
9
0
0
0
0
0
0
0
9
0
0
0
0
0
% W
% Tyr:
0
17
42
25
17
0
17
0
0
9
0
9
0
9
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _