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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMPDL3B
All Species:
19.7
Human Site:
T222
Identified Species:
39.39
UniProt:
Q92485
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92485
NP_001009568.1
455
50814
T222
Q
W
L
E
D
V
L
T
D
A
S
K
A
G
D
Chimpanzee
Pan troglodytes
XP_001151336
455
50854
T222
Q
W
L
E
D
V
L
T
N
A
S
K
A
G
D
Rhesus Macaque
Macaca mulatta
XP_001108274
453
51294
Q229
N
K
T
D
P
A
N
Q
F
E
W
L
E
S
T
Dog
Lupus familis
XP_544464
468
52011
T234
Q
W
L
E
E
V
L
T
N
A
S
R
A
K
E
Cat
Felis silvestris
Mouse
Mus musculus
P58242
456
51581
S222
R
W
L
G
D
V
L
S
N
A
S
R
D
G
E
Rat
Rattus norvegicus
Q641Z7
445
49877
A224
T
L
N
K
T
D
P
A
N
Q
F
E
W
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516772
436
49539
Q203
E
W
L
E
E
T
L
Q
G
S
R
Q
K
K
E
Chicken
Gallus gallus
XP_001232192
454
51318
T218
Q
W
L
E
E
T
L
T
N
A
S
K
A
E
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_692822
457
52265
Q224
S
W
A
D
K
V
L
Q
D
A
A
K
N
N
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_729555
488
55653
T229
L
W
L
E
E
V
L
T
K
S
K
E
K
Q
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_505620
755
86279
R226
N
A
E
K
C
P
N
R
I
S
E
N
C
T
S
Sea Urchin
Strong. purpuratus
XP_786766
452
51341
L224
F
D
W
L
E
D
T
L
E
A
A
Q
T
A
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
40.2
76.2
N.A.
75.6
39.3
N.A.
38
61
N.A.
54.2
N.A.
28.6
N.A.
23.8
39.3
Protein Similarity:
100
99.5
58
83.9
N.A.
86.1
58.4
N.A.
55.8
74
N.A.
71.1
N.A.
47.9
N.A.
37
58
P-Site Identity:
100
93.3
0
66.6
N.A.
53.3
0
N.A.
26.6
66.6
N.A.
40
N.A.
40
N.A.
0
6.6
P-Site Similarity:
100
100
6.6
93.3
N.A.
86.6
26.6
N.A.
60
86.6
N.A.
60
N.A.
66.6
N.A.
13.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
9
0
0
9
0
9
0
59
17
0
34
9
0
% A
% Cys:
0
0
0
0
9
0
0
0
0
0
0
0
9
0
0
% C
% Asp:
0
9
0
17
25
17
0
0
17
0
0
0
9
0
17
% D
% Glu:
9
0
9
50
42
0
0
0
9
9
9
17
9
9
59
% E
% Phe:
9
0
0
0
0
0
0
0
9
0
9
0
0
0
0
% F
% Gly:
0
0
0
9
0
0
0
0
9
0
0
0
0
25
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% I
% Lys:
0
9
0
17
9
0
0
0
9
0
9
34
17
17
0
% K
% Leu:
9
9
59
9
0
0
67
9
0
0
0
9
0
9
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
17
0
9
0
0
0
17
0
42
0
0
9
9
9
0
% N
% Pro:
0
0
0
0
9
9
9
0
0
0
0
0
0
0
0
% P
% Gln:
34
0
0
0
0
0
0
25
0
9
0
17
0
9
0
% Q
% Arg:
9
0
0
0
0
0
0
9
0
0
9
17
0
0
0
% R
% Ser:
9
0
0
0
0
0
0
9
0
25
42
0
0
9
9
% S
% Thr:
9
0
9
0
9
17
9
42
0
0
0
0
9
9
9
% T
% Val:
0
0
0
0
0
50
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
67
9
0
0
0
0
0
0
0
9
0
9
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _