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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMPDL3B
All Species:
26.36
Human Site:
Y287
Identified Species:
52.73
UniProt:
Q92485
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92485
NP_001009568.1
455
50814
Y287
T
D
S
F
R
M
L
Y
D
D
A
G
V
P
I
Chimpanzee
Pan troglodytes
XP_001151336
455
50854
Y287
T
D
S
F
R
M
L
Y
D
D
A
G
V
P
I
Rhesus Macaque
Macaca mulatta
XP_001108274
453
51294
F290
S
D
V
I
A
G
Q
F
Y
G
H
T
H
R
D
Dog
Lupus familis
XP_544464
468
52011
Y299
T
D
S
F
R
M
F
Y
D
D
A
G
A
P
I
Cat
Felis silvestris
Mouse
Mus musculus
P58242
456
51581
Y287
T
D
S
F
R
M
F
Y
D
N
T
G
A
P
I
Rat
Rattus norvegicus
Q641Z7
445
49877
I283
F
R
R
Y
S
S
V
I
A
G
Q
F
Y
G
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516772
436
49539
A268
R
D
S
L
M
V
L
A
D
D
Q
G
R
P
V
Chicken
Gallus gallus
XP_001232192
454
51318
Y283
T
D
S
F
R
M
F
Y
S
D
T
G
S
P
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_692822
457
52265
Y289
T
D
S
F
R
M
F
Y
N
S
K
G
S
P
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_729555
488
55653
Y298
S
D
T
F
R
L
I
Y
D
A
K
G
N
P
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_505620
755
86279
K291
T
D
T
F
H
L
I
K
D
S
K
E
N
N
V
Sea Urchin
Strong. purpuratus
XP_786766
452
51341
Y289
Y
D
S
F
R
I
L
Y
D
D
T
G
L
P
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
40.2
76.2
N.A.
75.6
39.3
N.A.
38
61
N.A.
54.2
N.A.
28.6
N.A.
23.8
39.3
Protein Similarity:
100
99.5
58
83.9
N.A.
86.1
58.4
N.A.
55.8
74
N.A.
71.1
N.A.
47.9
N.A.
37
58
P-Site Identity:
100
100
6.6
86.6
N.A.
73.3
0
N.A.
46.6
73.3
N.A.
66.6
N.A.
53.3
N.A.
26.6
73.3
P-Site Similarity:
100
100
20
86.6
N.A.
80
13.3
N.A.
60
73.3
N.A.
73.3
N.A.
80
N.A.
53.3
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
9
0
0
9
9
9
25
0
17
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
92
0
0
0
0
0
0
67
50
0
0
0
0
9
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% E
% Phe:
9
0
0
75
0
0
34
9
0
0
0
9
0
0
0
% F
% Gly:
0
0
0
0
0
9
0
0
0
17
0
75
0
9
0
% G
% His:
0
0
0
0
9
0
0
0
0
0
9
0
9
0
9
% H
% Ile:
0
0
0
9
0
9
17
9
0
0
0
0
0
0
67
% I
% Lys:
0
0
0
0
0
0
0
9
0
0
25
0
0
0
0
% K
% Leu:
0
0
0
9
0
17
34
0
0
0
0
0
9
0
0
% L
% Met:
0
0
0
0
9
50
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
9
9
0
0
17
9
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
75
0
% P
% Gln:
0
0
0
0
0
0
9
0
0
0
17
0
0
0
0
% Q
% Arg:
9
9
9
0
67
0
0
0
0
0
0
0
9
9
0
% R
% Ser:
17
0
67
0
9
9
0
0
9
17
0
0
17
0
0
% S
% Thr:
59
0
17
0
0
0
0
0
0
0
25
9
0
0
0
% T
% Val:
0
0
9
0
0
9
9
0
0
0
0
0
17
0
17
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
9
0
0
0
67
9
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _