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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD17B8
All Species:
12.42
Human Site:
T219
Identified Species:
30.37
UniProt:
Q92506
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92506
NP_055049.1
261
26974
T219
Q
K
V
V
D
K
I
T
E
M
I
P
M
G
H
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
NP_001108430
261
26939
T219
Q
K
V
V
D
K
I
T
E
M
I
P
M
G
Y
Dog
Lupus familis
XP_851004
259
26677
I217
Q
K
V
L
D
K
V
I
G
M
I
P
M
G
H
Cat
Felis silvestris
Mouse
Mus musculus
P50171
259
26570
T217
E
K
V
K
D
K
V
T
A
M
I
P
L
G
H
Rat
Rattus norvegicus
Q6MGB5
259
26772
T217
E
K
V
K
D
K
V
T
A
M
I
P
L
G
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001005292
256
26946
I216
I
D
K
I
T
S
I
I
P
L
G
R
M
G
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_570046
249
26195
L216
Q
R
C
P
L
G
R
L
G
Q
P
E
E
I
A
Honey Bee
Apis mellifera
XP_624870
246
26335
M213
K
R
I
P
L
H
R
M
G
K
P
E
E
V
A
Nematode Worm
Caenorhab. elegans
NP_499346
296
31226
V254
P
K
V
L
D
A
M
V
S
M
V
P
Q
R
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P33207
319
33530
L276
E
D
M
E
K
K
I
L
G
T
I
P
L
G
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
96.1
88.1
N.A.
86.9
86.9
N.A.
N.A.
N.A.
N.A.
60.1
N.A.
50.5
46.3
41.8
N.A.
Protein Similarity:
100
N.A.
98
91.1
N.A.
94.2
93.4
N.A.
N.A.
N.A.
N.A.
73.5
N.A.
67.8
67.4
59.7
N.A.
P-Site Identity:
100
N.A.
93.3
73.3
N.A.
66.6
66.6
N.A.
N.A.
N.A.
N.A.
20
N.A.
6.6
0
33.3
N.A.
P-Site Similarity:
100
N.A.
100
86.6
N.A.
86.6
86.6
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
13.3
20
53.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.2
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.9
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
10
0
0
20
0
0
0
0
0
20
% A
% Cys:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
20
0
0
60
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
30
0
0
10
0
0
0
0
20
0
0
20
20
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
10
0
0
40
0
10
0
0
70
0
% G
% His:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
40
% H
% Ile:
10
0
10
10
0
0
40
20
0
0
60
0
0
10
0
% I
% Lys:
10
60
10
20
10
60
0
0
0
10
0
0
0
0
0
% K
% Leu:
0
0
0
20
20
0
0
20
0
10
0
0
30
0
0
% L
% Met:
0
0
10
0
0
0
10
10
0
60
0
0
40
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
10
0
0
20
0
0
0
0
10
0
20
70
0
0
0
% P
% Gln:
40
0
0
0
0
0
0
0
0
10
0
0
10
0
0
% Q
% Arg:
0
20
0
0
0
0
20
0
0
0
0
10
0
10
20
% R
% Ser:
0
0
0
0
0
10
0
0
10
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
10
0
0
40
0
10
0
0
0
0
0
% T
% Val:
0
0
60
20
0
0
30
10
0
0
10
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _