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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD17B8
All Species:
33.03
Human Site:
Y247
Identified Species:
80.74
UniProt:
Q92506
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92506
NP_055049.1
261
26974
Y247
L
A
S
E
D
S
G
Y
I
T
G
T
S
V
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
NP_001108430
261
26939
Y247
L
A
S
E
D
S
G
Y
I
T
G
A
S
V
E
Dog
Lupus familis
XP_851004
259
26677
Y245
L
A
S
E
D
S
G
Y
I
T
G
A
S
V
E
Cat
Felis silvestris
Mouse
Mus musculus
P50171
259
26570
Y245
L
A
S
E
D
S
G
Y
I
T
G
A
S
V
E
Rat
Rattus norvegicus
Q6MGB5
259
26772
Y245
L
A
S
E
D
S
G
Y
I
T
G
A
S
V
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001005292
256
26946
Y241
L
A
S
D
D
S
R
Y
I
T
G
V
S
I
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_570046
249
26195
Y236
L
A
S
P
Q
S
S
Y
V
N
G
A
A
I
E
Honey Bee
Apis mellifera
XP_624870
246
26335
Y233
L
A
S
S
K
S
S
Y
I
N
G
A
S
I
D
Nematode Worm
Caenorhab. elegans
NP_499346
296
31226
Y282
L
A
S
D
M
S
S
Y
V
T
G
T
T
L
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P33207
319
33530
Y305
A
L
S
P
A
A
S
Y
I
T
G
Q
A
F
T
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
96.1
88.1
N.A.
86.9
86.9
N.A.
N.A.
N.A.
N.A.
60.1
N.A.
50.5
46.3
41.8
N.A.
Protein Similarity:
100
N.A.
98
91.1
N.A.
94.2
93.4
N.A.
N.A.
N.A.
N.A.
73.5
N.A.
67.8
67.4
59.7
N.A.
P-Site Identity:
100
N.A.
93.3
93.3
N.A.
93.3
93.3
N.A.
N.A.
N.A.
N.A.
73.3
N.A.
46.6
53.3
60
N.A.
P-Site Similarity:
100
N.A.
93.3
93.3
N.A.
93.3
93.3
N.A.
N.A.
N.A.
N.A.
86.6
N.A.
66.6
66.6
86.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.2
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.9
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
90
0
0
10
10
0
0
0
0
0
60
20
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
20
60
0
0
0
0
0
0
0
0
0
10
% D
% Glu:
0
0
0
50
0
0
0
0
0
0
0
0
0
0
80
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% F
% Gly:
0
0
0
0
0
0
50
0
0
0
100
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
80
0
0
0
0
30
0
% I
% Lys:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
90
10
0
0
0
0
0
0
0
0
0
0
0
10
0
% L
% Met:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
20
0
0
0
0
0
% N
% Pro:
0
0
0
20
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
10
0
0
0
0
0
0
10
0
0
0
% Q
% Arg:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
100
10
0
90
40
0
0
0
0
0
70
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
80
0
20
10
0
10
% T
% Val:
0
0
0
0
0
0
0
0
20
0
0
10
0
50
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
100
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _