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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RAPGEF5
All Species:
26.06
Human Site:
S375
Identified Species:
57.33
UniProt:
Q92565
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92565
NP_036426.3
580
67733
S375
E
L
I
Y
F
T
F
S
R
Q
G
S
G
E
H
Chimpanzee
Pan troglodytes
XP_518989
561
65098
A365
Q
G
S
G
E
H
T
A
N
L
S
L
L
L
Q
Rhesus Macaque
Macaca mulatta
XP_001100534
938
108135
S733
E
L
I
Y
F
T
F
S
R
Q
G
S
G
E
H
Dog
Lupus familis
XP_539466
579
67558
S373
E
L
I
Y
F
T
F
S
R
Q
G
S
G
E
H
Cat
Felis silvestris
Mouse
Mus musculus
Q8C0Q9
814
93706
S608
E
L
I
Y
F
T
F
S
R
Q
G
N
G
E
N
Rat
Rattus norvegicus
P83900
580
67583
S374
E
L
I
Y
F
T
F
S
R
Q
G
S
G
E
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513898
806
93569
S600
E
L
I
Y
F
T
F
S
R
Q
G
S
S
E
N
Chicken
Gallus gallus
XP_426579
1011
115518
G802
E
L
I
Y
H
T
F
G
R
H
N
F
K
K
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002665506
617
71296
S411
E
L
I
F
Y
T
F
S
R
Q
A
S
S
G
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34578
1234
141798
G1021
E
L
L
Y
Q
V
I
G
R
E
S
F
P
L
S
Sea Urchin
Strong. purpuratus
XP_784278
676
77986
G467
E
F
I
Y
H
T
F
G
R
H
K
Y
R
R
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82.5
59.5
97.4
N.A.
64.8
95.3
N.A.
62.7
27
N.A.
59.9
N.A.
N.A.
N.A.
20.5
34
Protein Similarity:
100
86.5
60.6
98.4
N.A.
68.1
97.2
N.A.
67.1
40.2
N.A.
76.5
N.A.
N.A.
N.A.
33
52.6
P-Site Identity:
100
0
100
100
N.A.
86.6
100
N.A.
86.6
46.6
N.A.
66.6
N.A.
N.A.
N.A.
26.6
40
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
93.3
53.3
N.A.
80
N.A.
N.A.
N.A.
40
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
10
0
0
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
91
0
0
0
10
0
0
0
0
10
0
0
0
55
0
% E
% Phe:
0
10
0
10
55
0
82
0
0
0
0
19
0
0
0
% F
% Gly:
0
10
0
10
0
0
0
28
0
0
55
0
46
10
0
% G
% His:
0
0
0
0
19
10
0
0
0
19
0
0
0
0
46
% H
% Ile:
0
0
82
0
0
0
10
0
0
0
0
0
0
0
10
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
10
0
10
10
0
% K
% Leu:
0
82
10
0
0
0
0
0
0
10
0
10
10
19
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
10
0
10
10
0
0
19
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% P
% Gln:
10
0
0
0
10
0
0
0
0
64
0
0
0
0
10
% Q
% Arg:
0
0
0
0
0
0
0
0
91
0
0
0
10
10
0
% R
% Ser:
0
0
10
0
0
0
0
64
0
0
19
55
19
0
10
% S
% Thr:
0
0
0
0
0
82
10
0
0
0
0
0
0
0
10
% T
% Val:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
82
10
0
0
0
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _