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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HSPH1 All Species: 27.88
Human Site: S562 Identified Species: 43.81
UniProt: Q92598 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92598 NP_006635.2 858 96865 S562 P P S P E L T S E E N K I P D
Chimpanzee Pan troglodytes XP_001142849 1091 122133 S795 P P S P E L T S E E N K I P D
Rhesus Macaque Macaca mulatta XP_001106968 840 94362 D562 G S K D K K M D Q P P Q A K K
Dog Lupus familis XP_534515 1048 117305 S752 P P S P E L T S E E N K I P D
Cat Felis silvestris
Mouse Mus musculus Q61699 858 96389 S563 P P S P E L T S E E S K T P D
Rat Rattus norvegicus Q66HA8 858 96400 S563 P P S P E L T S E E N K I P D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509055 859 95987 S563 P P P P E P P S E E H K I P D
Chicken Gallus gallus NP_001153170 856 96066 S562 P P S S E P P S E E N K I P D
Frog Xenopus laevis P02827 647 70897 T431 K Q T Q S F T T Y S D N Q P G
Zebra Danio Brachydanio rerio NP_956151 840 94728 Q568 K K S D Q P P Q A K K P K V K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VG58 641 70235 T425 I P C K Q T K T F S T Y S D N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q05036 776 86878 E560 V Q K F H N L E L Q M Q E S D
Sea Urchin Strong. purpuratus Q06068 889 98600 K582 S K S D K E S K D Q N S E G S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32589 693 77348 V476 L P E G Q D S V P V K L K L R
Red Bread Mold Neurospora crassa O74225 707 78655 I491 A R I N I H G I L N V E S A Y
Conservation
Percent
Protein Identity: 100 78.6 63.5 76.9 N.A. 93.4 92.4 N.A. 84.7 81.4 28.5 61.7 N.A. 27 N.A. 42 51.1
Protein Similarity: 100 78.6 77.9 79.6 N.A. 96.8 96.6 N.A. 92.5 90.7 45.7 77.3 N.A. 45.9 N.A. 58.9 67.9
P-Site Identity: 100 100 0 100 N.A. 86.6 100 N.A. 73.3 80 13.3 6.6 N.A. 6.6 N.A. 6.6 13.3
P-Site Similarity: 100 100 20 100 N.A. 93.3 100 N.A. 80 80 33.3 20 N.A. 26.6 N.A. 20 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. 33.5 36.3
Protein Similarity: N.A. N.A. N.A. N.A. 51 53
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 0
P-Site Similarity: N.A. N.A. N.A. N.A. 20 6.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 0 0 0 0 7 0 0 0 7 7 0 % A
% Cys: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 20 0 7 0 7 7 0 7 0 0 7 54 % D
% Glu: 0 0 7 0 47 7 0 7 47 47 0 7 14 0 0 % E
% Phe: 0 0 0 7 0 7 0 0 7 0 0 0 0 0 0 % F
% Gly: 7 0 0 7 0 0 7 0 0 0 0 0 0 7 7 % G
% His: 0 0 0 0 7 7 0 0 0 0 7 0 0 0 0 % H
% Ile: 7 0 7 0 7 0 0 7 0 0 0 0 40 0 0 % I
% Lys: 14 14 14 7 14 7 7 7 0 7 14 47 14 7 14 % K
% Leu: 7 0 0 0 0 34 7 0 14 0 0 7 0 7 0 % L
% Met: 0 0 0 0 0 0 7 0 0 0 7 0 0 0 0 % M
% Asn: 0 0 0 7 0 7 0 0 0 7 40 7 0 0 7 % N
% Pro: 47 60 7 40 0 20 20 0 7 7 7 7 0 54 0 % P
% Gln: 0 14 0 7 20 0 0 7 7 14 0 14 7 0 0 % Q
% Arg: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 7 % R
% Ser: 7 7 54 7 7 0 14 47 0 14 7 7 14 7 7 % S
% Thr: 0 0 7 0 0 7 40 14 0 0 7 0 7 0 0 % T
% Val: 7 0 0 0 0 0 0 7 0 7 7 0 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 7 0 0 7 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _