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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SORL1 All Species: 5.15
Human Site: S70 Identified Species: 14.17
UniProt: Q92673 Number Species: 8
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92673 NP_003096.1 2214 248441 S70 R G D A R G A S R A D E K P L
Chimpanzee Pan troglodytes XP_001156482 4034 452735 S679 D N D C G D M S D E K D C P T
Rhesus Macaque Macaca mulatta XP_001102178 2223 249098 G55 L F L R V P G G P Q W V E C M
Dog Lupus familis XP_536545 2204 246660 R60 G E A R G G P R G A A E A P P
Cat Felis silvestris
Mouse Mus musculus O88307 2215 247103 S70 H G D A P G A S P A A R K P L
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505297 2152 240021 R55 N V I V A L A R D S L A L P G
Chicken Gallus gallus Q98930 1592 178392
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392519 2132 240955 S58 R D I P S Q I S N N D P N I T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001198637 1175 132480
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 20.2 92.2 92.6 N.A. 93.2 N.A. N.A. 78.8 58.3 N.A. N.A. N.A. N.A. 32.6 N.A. 25.5
Protein Similarity: 100 32.5 94.1 96 N.A. 96.3 N.A. N.A. 87.3 64.8 N.A. N.A. N.A. N.A. 49.9 N.A. 35.8
P-Site Identity: 100 20 0 26.6 N.A. 66.6 N.A. N.A. 13.3 0 N.A. N.A. N.A. N.A. 20 N.A. 0
P-Site Similarity: 100 26.6 13.3 26.6 N.A. 66.6 N.A. N.A. 20 0 N.A. N.A. N.A. N.A. 20 N.A. 0
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 12 23 12 0 34 0 0 34 23 12 12 0 0 % A
% Cys: 0 0 0 12 0 0 0 0 0 0 0 0 12 12 0 % C
% Asp: 12 12 34 0 0 12 0 0 23 0 23 12 0 0 0 % D
% Glu: 0 12 0 0 0 0 0 0 0 12 0 23 12 0 0 % E
% Phe: 0 12 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 12 23 0 0 23 34 12 12 12 0 0 0 0 0 12 % G
% His: 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 23 0 0 0 12 0 0 0 0 0 0 12 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 12 0 23 0 0 % K
% Leu: 12 0 12 0 0 12 0 0 0 0 12 0 12 0 23 % L
% Met: 0 0 0 0 0 0 12 0 0 0 0 0 0 0 12 % M
% Asn: 12 12 0 0 0 0 0 0 12 12 0 0 12 0 0 % N
% Pro: 0 0 0 12 12 12 12 0 23 0 0 12 0 56 12 % P
% Gln: 0 0 0 0 0 12 0 0 0 12 0 0 0 0 0 % Q
% Arg: 23 0 0 23 12 0 0 23 12 0 0 12 0 0 0 % R
% Ser: 0 0 0 0 12 0 0 45 0 12 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 23 % T
% Val: 0 12 0 12 12 0 0 0 0 0 0 12 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 12 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _