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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTRA1
All Species:
13.94
Human Site:
S25
Identified Species:
27.88
UniProt:
Q92743
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92743
NP_002766.1
480
51287
S25
A
P
A
S
A
Q
L
S
R
A
G
R
S
A
P
Chimpanzee
Pan troglodytes
XP_508084
598
64926
C117
I
R
I
T
S
A
L
C
F
Y
H
F
T
V
G
Rhesus Macaque
Macaca mulatta
XP_001103628
481
51453
S26
A
P
A
S
A
Q
L
S
R
A
G
R
S
A
P
Dog
Lupus familis
XP_535044
364
39543
Cat
Felis silvestris
Mouse
Mus musculus
Q9R118
480
51228
S25
A
P
S
L
A
L
P
S
G
T
G
R
S
A
P
Rat
Rattus norvegicus
NP_113909
480
51312
S25
A
P
S
L
A
L
P
S
G
I
S
R
S
A
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510536
221
23778
Chicken
Gallus gallus
XP_420813
466
50374
S15
P
L
L
L
L
C
L
S
R
S
R
G
S
A
E
Frog
Xenopus laevis
NP_001088796
457
48812
P18
G
A
P
A
A
L
L
P
T
S
G
V
G
C
P
Zebra Danio
Brachydanio rerio
NP_001002219
479
51423
S23
L
Q
A
D
A
R
L
S
K
R
Y
V
I
G
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFJ3
422
45981
L22
R
C
I
A
S
P
V
L
H
S
H
A
A
N
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q3E6S8
459
49256
I48
S
S
K
R
S
E
L
I
R
I
I
S
V
A
T
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
68.9
99.1
71
N.A.
91
91.8
N.A.
44.5
57
65.6
69.7
N.A.
37
N.A.
N.A.
N.A.
Protein Similarity:
100
72
99.5
73.5
N.A.
93.9
94.5
N.A.
46
74.1
77.5
82.7
N.A.
56.2
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
100
0
N.A.
60
53.3
N.A.
0
33.3
26.6
26.6
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
26.6
100
0
N.A.
66.6
60
N.A.
0
40
40
40
N.A.
33.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
29.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.4
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
34
9
25
17
50
9
0
0
0
17
0
9
9
50
0
% A
% Cys:
0
9
0
0
0
9
0
9
0
0
0
0
0
9
0
% C
% Asp:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
9
% E
% Phe:
0
0
0
0
0
0
0
0
9
0
0
9
0
0
0
% F
% Gly:
9
0
0
0
0
0
0
0
17
0
34
9
9
9
17
% G
% His:
0
0
0
0
0
0
0
0
9
0
17
0
0
0
0
% H
% Ile:
9
0
17
0
0
0
0
9
0
17
9
0
9
0
0
% I
% Lys:
0
0
9
0
0
0
0
0
9
0
0
0
0
0
0
% K
% Leu:
9
9
9
25
9
25
59
9
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% N
% Pro:
9
34
9
0
0
9
17
9
0
0
0
0
0
0
42
% P
% Gln:
0
9
0
0
0
17
0
0
0
0
0
0
0
0
0
% Q
% Arg:
9
9
0
9
0
9
0
0
34
9
9
34
0
0
9
% R
% Ser:
9
9
17
17
25
0
0
50
0
25
9
9
42
0
0
% S
% Thr:
0
0
0
9
0
0
0
0
9
9
0
0
9
0
9
% T
% Val:
0
0
0
0
0
0
9
0
0
0
0
17
9
9
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
9
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _