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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTRA1
All Species:
36.97
Human Site:
S298
Identified Species:
73.94
UniProt:
Q92743
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92743
NP_002766.1
480
51287
S298
T
V
T
T
G
I
V
S
T
T
Q
R
G
G
K
Chimpanzee
Pan troglodytes
XP_508084
598
64926
S416
T
V
T
T
G
I
V
S
T
T
Q
R
G
G
K
Rhesus Macaque
Macaca mulatta
XP_001103628
481
51453
S299
T
V
T
T
G
I
V
S
T
T
Q
R
G
G
K
Dog
Lupus familis
XP_535044
364
39543
R186
G
I
V
S
T
T
Q
R
G
G
K
E
L
G
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9R118
480
51228
S298
T
V
T
T
G
I
V
S
T
T
Q
R
G
G
K
Rat
Rattus norvegicus
NP_113909
480
51312
S298
T
V
T
T
G
I
V
S
T
T
Q
R
G
G
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510536
221
23778
R43
G
I
V
S
T
T
Q
R
G
G
K
E
L
G
L
Chicken
Gallus gallus
XP_420813
466
50374
S288
T
V
T
T
G
I
V
S
T
A
Q
R
D
G
K
Frog
Xenopus laevis
NP_001088796
457
48812
S275
T
V
T
T
G
I
V
S
T
A
Q
R
G
G
K
Zebra Danio
Brachydanio rerio
NP_001002219
479
51423
S297
T
V
T
T
G
I
V
S
T
T
Q
R
G
G
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFJ3
422
45981
S236
T
V
T
A
G
V
I
S
S
T
Q
R
A
S
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q3E6S8
459
49256
S281
T
V
T
A
G
I
V
S
C
V
D
R
K
S
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
68.9
99.1
71
N.A.
91
91.8
N.A.
44.5
57
65.6
69.7
N.A.
37
N.A.
N.A.
N.A.
Protein Similarity:
100
72
99.5
73.5
N.A.
93.9
94.5
N.A.
46
74.1
77.5
82.7
N.A.
56.2
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
6.6
N.A.
100
100
N.A.
6.6
86.6
93.3
100
N.A.
53.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
26.6
N.A.
100
100
N.A.
26.6
86.6
93.3
100
N.A.
80
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
29.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.4
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
53.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
17
0
0
0
0
0
17
0
0
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
9
0
9
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
17
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
17
0
0
0
84
0
0
0
17
17
0
0
59
84
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
17
0
0
0
75
9
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
17
0
9
0
67
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
17
0
17
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
17
0
0
0
75
0
0
0
9
% Q
% Arg:
0
0
0
0
0
0
0
17
0
0
0
84
0
0
0
% R
% Ser:
0
0
0
17
0
0
0
84
9
0
0
0
0
17
9
% S
% Thr:
84
0
84
67
17
17
0
0
67
59
0
0
0
0
0
% T
% Val:
0
84
17
0
0
9
75
0
0
9
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _