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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTRA1
All Species:
25.76
Human Site:
T457
Identified Species:
51.52
UniProt:
Q92743
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92743
NP_002766.1
480
51287
T457
D
V
I
K
R
E
S
T
L
N
M
V
V
R
R
Chimpanzee
Pan troglodytes
XP_508084
598
64926
T575
D
V
I
K
R
E
S
T
L
N
M
V
V
R
R
Rhesus Macaque
Macaca mulatta
XP_001103628
481
51453
T458
D
V
I
K
R
E
S
T
L
N
M
V
V
R
R
Dog
Lupus familis
XP_535044
364
39543
L342
V
I
K
K
E
N
T
L
N
M
V
V
R
R
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9R118
480
51228
T457
D
V
I
K
K
E
N
T
L
N
M
V
V
R
R
Rat
Rattus norvegicus
NP_113909
480
51312
T457
D
V
I
K
K
E
N
T
L
N
M
V
V
R
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510536
221
23778
L199
V
I
K
K
E
S
T
L
N
M
V
V
R
R
G
Chicken
Gallus gallus
XP_420813
466
50374
P444
E
A
V
M
N
E
S
P
L
L
L
E
V
R
R
Frog
Xenopus laevis
NP_001088796
457
48812
T434
E
A
I
K
K
E
G
T
L
Q
M
V
I
R
R
Zebra Danio
Brachydanio rerio
NP_001002219
479
51423
S456
A
I
I
K
K
E
S
S
L
R
V
V
V
R
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFJ3
422
45981
K400
D
A
L
A
D
N
S
K
T
L
D
I
V
I
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q3E6S8
459
49256
V437
V
G
K
R
M
Q
V
V
V
E
R
S
N
K
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
68.9
99.1
71
N.A.
91
91.8
N.A.
44.5
57
65.6
69.7
N.A.
37
N.A.
N.A.
N.A.
Protein Similarity:
100
72
99.5
73.5
N.A.
93.9
94.5
N.A.
46
74.1
77.5
82.7
N.A.
56.2
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
20
N.A.
86.6
86.6
N.A.
20
40
60
60
N.A.
20
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
40
N.A.
100
100
N.A.
40
60
80
86.6
N.A.
33.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
29.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.4
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
25
0
9
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
50
0
0
0
9
0
0
0
0
0
9
0
0
0
0
% D
% Glu:
17
0
0
0
17
67
0
0
0
9
0
9
0
0
9
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
9
0
0
0
0
9
0
0
0
0
0
0
0
17
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
25
59
0
0
0
0
0
0
0
0
9
9
9
0
% I
% Lys:
0
0
25
75
34
0
0
9
0
0
0
0
0
9
0
% K
% Leu:
0
0
9
0
0
0
0
17
67
17
9
0
0
0
9
% L
% Met:
0
0
0
9
9
0
0
0
0
17
50
0
0
0
0
% M
% Asn:
0
0
0
0
9
17
17
0
17
42
0
0
9
0
0
% N
% Pro:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
9
0
0
0
9
0
0
0
0
0
% Q
% Arg:
0
0
0
9
25
0
0
0
0
9
9
0
17
84
67
% R
% Ser:
0
0
0
0
0
9
50
9
0
0
0
9
0
0
0
% S
% Thr:
0
0
0
0
0
0
17
50
9
0
0
0
0
0
0
% T
% Val:
25
42
9
0
0
0
9
9
9
0
25
75
67
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _