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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HTRA1 All Species: 31.82
Human Site: Y325 Identified Species: 63.64
UniProt: Q92743 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92743 NP_002766.1 480 51287 Y325 Q T D A I I N Y G N S G G P L
Chimpanzee Pan troglodytes XP_508084 598 64926 Y443 Q T D A I I N Y G N S G G P L
Rhesus Macaque Macaca mulatta XP_001103628 481 51453 Y326 Q T D A I I N Y G N S G G P L
Dog Lupus familis XP_535044 364 39543 G213 I I N Y G N S G G P L V N L D
Cat Felis silvestris
Mouse Mus musculus Q9R118 480 51228 Y325 Q T D A I I N Y G N S G G P L
Rat Rattus norvegicus NP_113909 480 51312 Y325 Q T D A I I N Y G N S G G P L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510536 221 23778 G70 I I N Y G N S G G P L V N L D
Chicken Gallus gallus XP_420813 466 50374 Y315 Q T D A I I N Y G N S G G P L
Frog Xenopus laevis NP_001088796 457 48812 Y302 Q T D A I I N Y G N S G G P L
Zebra Danio Brachydanio rerio NP_001002219 479 51423 Y324 Q T D A I I N Y G N S G G P L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VFJ3 422 45981 F263 Q T D A A I T F G N S G G P L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q3E6S8 459 49256 A308 Q T D C S I N A G N S G G P L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 68.9 99.1 71 N.A. 91 91.8 N.A. 44.5 57 65.6 69.7 N.A. 37 N.A. N.A. N.A.
Protein Similarity: 100 72 99.5 73.5 N.A. 93.9 94.5 N.A. 46 74.1 77.5 82.7 N.A. 56.2 N.A. N.A. N.A.
P-Site Identity: 100 100 100 6.6 N.A. 100 100 N.A. 6.6 100 100 100 N.A. 80 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 20 N.A. 100 100 N.A. 20 100 100 100 N.A. 86.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 29.5 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 46.4 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 80 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 80 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 75 9 0 0 9 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 84 0 0 0 0 0 0 0 0 0 0 0 17 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 17 0 0 17 100 0 0 84 84 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 17 17 0 0 67 84 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 17 0 0 17 84 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 17 0 0 17 75 0 0 84 0 0 17 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 17 0 0 0 84 0 % P
% Gln: 84 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 9 0 17 0 0 0 84 0 0 0 0 % S
% Thr: 0 84 0 0 0 0 9 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 17 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 17 0 0 0 67 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _