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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HTRA1 All Species: 25.45
Human Site: Y382 Identified Species: 50.91
UniProt: Q92743 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92743 NP_002766.1 480 51287 Y382 K A I T K K K Y I G I R M M S
Chimpanzee Pan troglodytes XP_508084 598 64926 Y500 K A I T K K K Y I G I R M M S
Rhesus Macaque Macaca mulatta XP_001103628 481 51453 Y383 K A I T K K K Y I G I R M M S
Dog Lupus familis XP_535044 364 39543 I269 T K K K Y I G I R M M S L T S
Cat Felis silvestris
Mouse Mus musculus Q9R118 480 51228 Y382 K A V T K K K Y I G I R M M S
Rat Rattus norvegicus NP_113909 480 51312 Y382 K T V T K K K Y I G I R M M S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510536 221 23778 I126 T K K K Y I G I R M M S L T S
Chicken Gallus gallus XP_420813 466 50374 G371 D S K K R F I G I R M L T I T
Frog Xenopus laevis NP_001088796 457 48812 Y359 Q G T K K K K Y L G I R M M S
Zebra Danio Brachydanio rerio NP_001002219 479 51423 Y381 R G T T K K R Y I G V R M M T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VFJ3 422 45981 P320 S A Y K T G Y P V K R Y M G I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q3E6S8 459 49256 G364 R V I R P W I G L K M V E L N
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 68.9 99.1 71 N.A. 91 91.8 N.A. 44.5 57 65.6 69.7 N.A. 37 N.A. N.A. N.A.
Protein Similarity: 100 72 99.5 73.5 N.A. 93.9 94.5 N.A. 46 74.1 77.5 82.7 N.A. 56.2 N.A. N.A. N.A.
P-Site Identity: 100 100 100 6.6 N.A. 93.3 86.6 N.A. 6.6 6.6 66.6 60 N.A. 13.3 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 20 N.A. 100 93.3 N.A. 20 40 80 86.6 N.A. 20 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 29.5 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 46.4 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 40 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 42 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % E
% Phe: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 17 0 0 0 9 17 17 0 59 0 0 0 9 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 34 0 0 17 17 17 59 0 50 0 0 9 9 % I
% Lys: 42 17 25 42 59 59 50 0 0 17 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 17 0 0 9 17 9 0 % L
% Met: 0 0 0 0 0 0 0 0 0 17 34 0 67 59 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % N
% Pro: 0 0 0 0 9 0 0 9 0 0 0 0 0 0 0 % P
% Gln: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 17 0 0 9 9 0 9 0 17 9 9 59 0 0 0 % R
% Ser: 9 9 0 0 0 0 0 0 0 0 0 17 0 0 67 % S
% Thr: 17 9 17 50 9 0 0 0 0 0 0 0 9 17 17 % T
% Val: 0 9 17 0 0 0 0 0 9 0 9 9 0 0 0 % V
% Trp: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 9 0 17 0 9 59 0 0 0 9 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _