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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GTF2H4 All Species: 28.48
Human Site: Y282 Identified Species: 62.67
UniProt: Q92759 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92759 NP_001508.1 462 52186 Y282 K R K S R R Y Y P T R L A I N
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_848919 463 52255 Y283 K R K S R R Y Y P T R L A I N
Cat Felis silvestris
Mouse Mus musculus O70422 463 52206 Y283 K R K S R R Y Y P T R L A I N
Rat Rattus norvegicus NP_997666 463 52193 Y283 K R K S R R Y Y P T R L A I N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513954 472 52374 Y282 K R K S R R Y Y P T R L A I N
Chicken Gallus gallus
Frog Xenopus laevis NP_001085110 455 51896 Y275 K R K S R R Y Y P T R L A I N
Zebra Danio Brachydanio rerio NP_956221 466 52671 V286 A I T L A A G V T A N P A S G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648780 499 56633 N312 Y P T R L A L N V T S K E A A
Honey Bee Apis mellifera XP_395476 467 53265 P285 R K A G R F Y P T R L A L N I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796111 469 52883 Y287 K R K S M R Y Y P T R L A I N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q02939 513 58516 S314 E D G A N G K S T T D I T T S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 98.9 N.A. 98.6 98.9 N.A. 58.2 N.A. 83.1 77.9 N.A. 49 57.5 N.A. 57.5
Protein Similarity: 100 N.A. N.A. 99.3 N.A. 99.1 99.3 N.A. 64.4 N.A. 90.9 87.1 N.A. 65.9 74 N.A. 76.3
P-Site Identity: 100 N.A. N.A. 100 N.A. 100 100 N.A. 100 N.A. 100 6.6 N.A. 6.6 13.3 N.A. 93.3
P-Site Similarity: 100 N.A. N.A. 100 N.A. 100 100 N.A. 100 N.A. 100 6.6 N.A. 6.6 26.6 N.A. 93.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 35.8 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 56.7 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 10 10 10 19 0 0 0 10 0 10 73 10 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 10 0 0 0 0 0 0 0 0 10 0 0 0 0 % D
% Glu: 10 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % E
% Phe: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 10 10 0 10 10 0 0 0 0 0 0 0 10 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 10 0 0 0 0 0 0 0 0 0 10 0 64 10 % I
% Lys: 64 10 64 0 0 0 10 0 0 0 0 10 0 0 0 % K
% Leu: 0 0 0 10 10 0 10 0 0 0 10 64 10 0 0 % L
% Met: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 10 0 0 10 0 0 10 0 0 10 64 % N
% Pro: 0 10 0 0 0 0 0 10 64 0 0 10 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 10 64 0 10 64 64 0 0 0 10 64 0 0 0 0 % R
% Ser: 0 0 0 64 0 0 0 10 0 0 10 0 0 10 10 % S
% Thr: 0 0 19 0 0 0 0 0 28 82 0 0 10 10 0 % T
% Val: 0 0 0 0 0 0 0 10 10 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 10 0 0 0 0 0 73 64 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _