KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC2
All Species:
36.36
Human Site:
S422
Identified Species:
57.14
UniProt:
Q92769
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92769
NP_001518.2
488
55364
S422
I
A
C
D
E
E
F
S
D
S
E
D
E
G
E
Chimpanzee
Pan troglodytes
XP_518700
581
65611
S515
I
A
C
D
E
E
F
S
D
S
E
D
E
G
E
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532270
481
54585
S415
I
A
C
D
E
E
F
S
D
S
E
D
E
G
E
Cat
Felis silvestris
Mouse
Mus musculus
P70288
488
55284
S422
I
A
C
D
E
E
F
S
D
S
E
D
E
G
E
Rat
Rattus norvegicus
Q4QQW4
482
55074
S421
I
A
C
E
E
E
F
S
D
S
D
E
E
G
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521848
455
51607
I402
G
E
D
P
D
K
R
I
S
I
R
A
S
D
K
Chicken
Gallus gallus
P56519
488
55134
S422
I
A
C
D
E
E
F
S
D
S
E
D
E
G
E
Frog
Xenopus laevis
O42227
480
54874
S421
I
A
C
D
E
E
F
S
D
S
E
D
E
G
E
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
R378
H
A
P
S
V
Q
I
R
D
V
P
S
D
L
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
S419
I
V
P
E
N
E
Y
S
D
S
E
D
E
G
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17695
461
52119
A406
D
S
L
I
A
D
Q
A
N
P
D
K
R
L
P
Sea Urchin
Strong. purpuratus
P56518
576
64060
S421
I
Q
R
D
D
E
F
S
D
S
E
D
E
G
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
G445
I
K
I
K
R
E
F
G
E
N
A
T
R
V
Q
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FML2
471
52633
I418
E
T
R
P
K
P
R
I
W
S
G
T
A
T
Y
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
T383
I
F
A
N
L
E
N
T
K
Y
A
P
S
V
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.9
N.A.
96.5
N.A.
99.3
85.8
N.A.
90.7
98.1
87.6
52.6
N.A.
73.3
N.A.
58.8
69.1
Protein Similarity:
100
83.9
N.A.
97.3
N.A.
99.3
93.6
N.A.
91.1
98.1
94.4
70.6
N.A.
81.9
N.A.
76
78.4
P-Site Identity:
100
100
N.A.
100
N.A.
100
80
N.A.
0
100
100
13.3
N.A.
66.6
N.A.
0
80
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
20
100
100
26.6
N.A.
80
N.A.
33.3
86.6
Percent
Protein Identity:
N.A.
53.6
N.A.
56.3
53.8
N.A.
Protein Similarity:
N.A.
70.5
N.A.
72.3
69.4
N.A.
P-Site Identity:
N.A.
20
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
40
N.A.
13.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
54
7
0
7
0
0
7
0
0
14
7
7
0
0
% A
% Cys:
0
0
47
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
7
47
14
7
0
0
67
0
14
54
7
7
0
% D
% Glu:
7
7
0
14
47
74
0
0
7
0
54
7
60
0
60
% E
% Phe:
0
7
0
0
0
0
60
0
0
0
0
0
0
0
0
% F
% Gly:
7
0
0
0
0
0
0
7
0
0
7
0
0
60
0
% G
% His:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
74
0
7
7
0
0
7
14
0
7
0
0
0
0
0
% I
% Lys:
0
7
0
7
7
7
0
0
7
0
0
7
0
0
7
% K
% Leu:
0
0
7
0
7
0
0
0
0
0
0
0
0
14
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
7
0
7
0
7
7
0
0
0
0
0
% N
% Pro:
0
0
14
14
0
7
0
0
0
7
7
7
0
0
7
% P
% Gln:
0
7
0
0
0
7
7
0
0
0
0
0
0
0
14
% Q
% Arg:
0
0
14
0
7
0
14
7
0
0
7
0
14
0
0
% R
% Ser:
0
7
0
7
0
0
0
60
7
67
0
7
14
0
0
% S
% Thr:
0
7
0
0
0
0
0
7
0
0
0
14
0
7
0
% T
% Val:
0
7
0
0
7
0
0
0
0
7
0
0
0
14
0
% V
% Trp:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
7
0
0
7
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _