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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC2
All Species:
40.61
Human Site:
T352
Identified Species:
63.81
UniProt:
Q92769
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92769
NP_001518.2
488
55364
T352
H
I
S
P
S
N
M
T
N
Q
N
T
P
E
Y
Chimpanzee
Pan troglodytes
XP_518700
581
65611
T445
H
I
S
P
S
N
M
T
N
Q
N
T
P
E
Y
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532270
481
54585
T345
H
I
S
P
S
N
M
T
N
Q
N
T
P
E
Y
Cat
Felis silvestris
Mouse
Mus musculus
P70288
488
55284
T352
H
I
S
P
S
N
M
T
N
Q
N
T
P
E
Y
Rat
Rattus norvegicus
Q4QQW4
482
55074
T351
H
I
S
P
S
N
M
T
N
Q
N
T
N
E
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521848
455
51607
T348
H
I
S
P
S
N
M
T
N
Q
N
T
P
E
Y
Chicken
Gallus gallus
P56519
488
55134
T352
H
I
S
P
S
N
M
T
N
Q
N
T
P
E
Y
Frog
Xenopus laevis
O42227
480
54874
T351
H
I
S
P
S
N
M
T
N
Q
N
T
N
E
Y
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
Y328
D
E
L
P
Y
S
E
Y
F
E
Y
F
A
P
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
T349
H
I
S
P
S
N
M
T
N
Q
N
T
S
E
Y
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17695
461
52119
A355
H
I
E
S
S
N
A
A
N
E
N
S
S
D
M
Sea Urchin
Strong. purpuratus
P56518
576
64060
T350
H
I
S
P
S
N
M
T
N
Q
N
T
G
E
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
E364
H
V
A
P
S
N
M
E
N
K
N
T
R
Q
Q
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FML2
471
52633
E363
H
V
D
P
S
P
M
E
N
L
N
T
P
K
D
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
V333
T
G
L
L
N
N
V
V
L
D
K
D
L
P
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.9
N.A.
96.5
N.A.
99.3
85.8
N.A.
90.7
98.1
87.6
52.6
N.A.
73.3
N.A.
58.8
69.1
Protein Similarity:
100
83.9
N.A.
97.3
N.A.
99.3
93.6
N.A.
91.1
98.1
94.4
70.6
N.A.
81.9
N.A.
76
78.4
P-Site Identity:
100
100
N.A.
100
N.A.
100
93.3
N.A.
100
100
93.3
6.6
N.A.
93.3
N.A.
40
93.3
P-Site Similarity:
100
100
N.A.
100
N.A.
100
93.3
N.A.
100
100
93.3
20
N.A.
93.3
N.A.
60
93.3
Percent
Protein Identity:
N.A.
53.6
N.A.
56.3
53.8
N.A.
Protein Similarity:
N.A.
70.5
N.A.
72.3
69.4
N.A.
P-Site Identity:
N.A.
53.3
N.A.
53.3
13.3
N.A.
P-Site Similarity:
N.A.
80
N.A.
66.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
0
0
7
7
0
0
0
0
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
7
0
0
0
0
0
0
7
0
7
0
7
14
% D
% Glu:
0
7
7
0
0
0
7
14
0
14
0
0
0
67
0
% E
% Phe:
0
0
0
0
0
0
0
0
7
0
0
7
0
0
0
% F
% Gly:
0
7
0
0
0
0
0
0
0
0
0
0
7
0
0
% G
% His:
87
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
74
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
7
7
0
0
7
0
% K
% Leu:
0
0
14
7
0
0
0
0
7
7
0
0
7
0
0
% L
% Met:
0
0
0
0
0
0
80
0
0
0
0
0
0
0
7
% M
% Asn:
0
0
0
0
7
87
0
0
87
0
87
0
14
0
0
% N
% Pro:
0
0
0
87
0
7
0
0
0
0
0
0
47
14
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
67
0
0
0
7
7
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% R
% Ser:
0
0
67
7
87
7
0
0
0
0
0
7
14
0
0
% S
% Thr:
7
0
0
0
0
0
0
67
0
0
0
80
0
0
0
% T
% Val:
0
14
0
0
0
0
7
7
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
0
0
7
0
0
7
0
0
0
74
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _