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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC2
All Species:
20
Human Site:
Y55
Identified Species:
31.43
UniProt:
Q92769
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92769
NP_001518.2
488
55364
Y55
L
Y
R
K
M
E
I
Y
R
P
H
K
A
T
A
Chimpanzee
Pan troglodytes
XP_518700
581
65611
Y148
L
Y
R
K
M
E
I
Y
R
P
H
K
A
T
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532270
481
54585
E57
P
H
K
A
T
A
E
E
M
T
K
Y
H
S
D
Cat
Felis silvestris
Mouse
Mus musculus
P70288
488
55284
Y55
L
Y
R
K
M
E
I
Y
R
P
H
K
A
T
A
Rat
Rattus norvegicus
Q4QQW4
482
55074
R55
Y
R
K
M
E
I
Y
R
P
H
K
A
N
A
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521848
455
51607
A56
E
I
Y
R
P
H
K
A
T
A
E
E
M
T
K
Chicken
Gallus gallus
P56519
488
55134
Y55
L
Y
R
K
M
E
I
Y
R
P
H
K
A
T
A
Frog
Xenopus laevis
O42227
480
54874
R55
Y
R
K
M
E
I
Y
R
P
H
K
A
S
A
E
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
K43
V
L
H
Y
G
L
Y
K
K
M
M
V
F
K
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
A57
E
I
Y
R
P
H
K
A
T
A
D
E
M
T
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17695
461
52119
F58
L
Y
R
N
L
E
I
F
R
P
F
P
A
S
F
Sea Urchin
Strong. purpuratus
P56518
576
64060
H56
K
M
E
I
Y
R
P
H
K
A
V
M
E
E
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
Y68
L
L
N
Q
M
Q
V
Y
R
P
N
P
A
R
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FML2
471
52633
S64
L
H
R
R
L
E
I
S
R
P
S
L
A
D
A
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
A48
K
P
H
R
I
R
M
A
H
S
L
I
M
N
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.9
N.A.
96.5
N.A.
99.3
85.8
N.A.
90.7
98.1
87.6
52.6
N.A.
73.3
N.A.
58.8
69.1
Protein Similarity:
100
83.9
N.A.
97.3
N.A.
99.3
93.6
N.A.
91.1
98.1
94.4
70.6
N.A.
81.9
N.A.
76
78.4
P-Site Identity:
100
100
N.A.
0
N.A.
100
0
N.A.
6.6
100
0
0
N.A.
6.6
N.A.
53.3
0
P-Site Similarity:
100
100
N.A.
20
N.A.
100
6.6
N.A.
20
100
13.3
13.3
N.A.
20
N.A.
73.3
13.3
Percent
Protein Identity:
N.A.
53.6
N.A.
56.3
53.8
N.A.
Protein Similarity:
N.A.
70.5
N.A.
72.3
69.4
N.A.
P-Site Identity:
N.A.
40
N.A.
53.3
0
N.A.
P-Site Similarity:
N.A.
66.6
N.A.
73.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
7
0
20
0
20
0
14
47
14
34
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
7
0
0
7
7
% D
% Glu:
14
0
7
0
14
40
7
7
0
0
7
14
7
7
20
% E
% Phe:
0
0
0
0
0
0
0
7
0
0
7
0
7
0
7
% F
% Gly:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
14
14
0
0
14
0
7
7
14
27
0
7
0
0
% H
% Ile:
0
14
0
7
7
14
40
0
0
0
0
7
0
0
0
% I
% Lys:
14
0
20
27
0
0
14
7
14
0
20
27
0
7
14
% K
% Leu:
47
14
0
0
14
7
0
0
0
0
7
7
0
0
0
% L
% Met:
0
7
0
14
34
0
7
0
7
7
7
7
20
0
7
% M
% Asn:
0
0
7
7
0
0
0
0
0
0
7
0
7
7
0
% N
% Pro:
7
7
0
0
14
0
7
0
14
47
0
14
0
0
7
% P
% Gln:
0
0
0
7
0
7
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
14
40
27
0
14
0
14
47
0
0
0
0
7
0
% R
% Ser:
0
0
0
0
0
0
0
7
0
7
7
0
7
14
0
% S
% Thr:
0
0
0
0
7
0
0
0
14
7
0
0
0
40
0
% T
% Val:
7
0
0
0
0
0
7
0
0
0
7
7
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
14
34
14
7
7
0
20
34
0
0
0
7
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _