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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDKL2
All Species:
22.12
Human Site:
Y77
Identified Species:
40.56
UniProt:
Q92772
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92772
NP_003939.1
493
56019
Y77
C
K
K
K
K
R
W
Y
L
V
F
E
F
V
D
Chimpanzee
Pan troglodytes
XP_001153844
566
64313
K53
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
Rhesus Macaque
Macaca mulatta
NP_001129485
570
64691
Y77
C
K
K
K
K
R
W
Y
L
V
F
E
F
V
D
Dog
Lupus familis
XP_535605
561
63942
Y77
C
K
K
K
K
R
W
Y
L
V
F
E
F
V
D
Cat
Felis silvestris
Mouse
Mus musculus
Q9QUK0
568
64037
Y77
C
K
K
K
K
R
W
Y
L
V
F
E
F
V
D
Rat
Rattus norvegicus
Q5XIT0
507
57117
Y77
C
K
K
K
K
R
W
Y
L
V
F
E
F
V
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512927
637
71445
H76
F
R
Q
K
K
K
I
H
L
V
F
E
F
I
D
Chicken
Gallus gallus
P13863
303
34670
Frog
Xenopus laevis
P35567
302
34487
Zebra Danio
Brachydanio rerio
Q6AXJ9
350
40792
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P23572
297
34420
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784044
926
104004
Y77
F
R
R
K
K
R
L
Y
L
V
F
E
F
M
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
79.5
84
78.2
N.A.
74.8
81.8
N.A.
38.1
29.8
30.2
39.1
N.A.
27.9
N.A.
N.A.
33.5
Protein Similarity:
100
81.8
84.9
82.1
N.A.
80.2
86.9
N.A.
55.7
41.7
43.8
53.5
N.A.
41.7
N.A.
N.A.
44.2
P-Site Identity:
100
6.6
100
100
N.A.
100
100
N.A.
53.3
0
0
0
N.A.
0
N.A.
N.A.
66.6
P-Site Similarity:
100
26.6
100
100
N.A.
100
100
N.A.
86.6
0
0
0
N.A.
0
N.A.
N.A.
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.7
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
39
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
54
% D
% Glu:
0
0
0
0
0
8
0
0
0
0
0
54
0
0
0
% E
% Phe:
16
0
0
0
0
0
0
0
0
0
54
0
54
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
8
% H
% Ile:
0
8
0
0
0
0
16
0
0
0
0
0
0
8
0
% I
% Lys:
8
39
39
54
54
8
0
8
0
0
8
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
8
0
62
8
0
0
8
0
0
% L
% Met:
0
0
0
8
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
0
0
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
0
16
8
0
8
47
0
0
0
0
0
0
0
8
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
54
0
0
0
39
0
% V
% Trp:
0
0
0
0
0
0
39
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
47
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _