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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PROX1 All Species: 21.82
Human Site: S545 Identified Species: 40
UniProt: Q92786 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92786 NP_002754.2 737 83203 S545 C S P A H P P S T A E G L S L
Chimpanzee Pan troglodytes XP_522907 592 65532 L409 T S A H L E S L P L L P S V K
Rhesus Macaque Macaca mulatta XP_001088672 592 65588 L409 T S A H L E S L P L L P S V K
Dog Lupus familis XP_858135 737 83203 S545 C S P A H P P S T A E G L S L
Cat Felis silvestris
Mouse Mus musculus P48437 737 83108 S545 C S P A H P P S T A E G L S L
Rat Rattus norvegicus NP_001100671 583 64827 H400 F A V N G E N H N F H T A N Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511202 735 83058 S543 C S P A H P P S T A E S L S L
Chicken Gallus gallus Q91018 736 83123 S544 C S P A H P P S A A E G L S L
Frog Xenopus laevis NP_001084172 740 83918 S546 C S P A H P P S S T E G L S L
Zebra Danio Brachydanio rerio NP_571480 739 83196 P547 R S I S P T H P G N E G L S L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392355 1146 126812 G956 L L A A A Q H G S P D Y G H L
Nematode Worm Caenorhab. elegans P34522 586 65798 F403 G H Y G G M N F G D R E D S P
Sea Urchin Strong. purpuratus XP_781578 723 81042 K532 S P A Y S M V K P E G R D T S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 33.6 33.2 99.3 N.A. 98.3 77.6 N.A. 95.6 93.6 87.9 82.6 N.A. N.A. 23.4 26.5 35
Protein Similarity: 100 46 46.5 99.5 N.A. 99.4 78.5 N.A. 98 96.1 93.7 89.3 N.A. N.A. 36.9 45 51
P-Site Identity: 100 6.6 6.6 100 N.A. 100 0 N.A. 93.3 93.3 86.6 40 N.A. N.A. 13.3 6.6 0
P-Site Similarity: 100 6.6 6.6 100 N.A. 100 13.3 N.A. 93.3 93.3 93.3 46.6 N.A. N.A. 26.6 6.6 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 31 54 8 0 0 0 8 39 0 0 8 0 0 % A
% Cys: 47 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 8 8 0 16 0 0 % D
% Glu: 0 0 0 0 0 24 0 0 0 8 54 8 0 0 0 % E
% Phe: 8 0 0 0 0 0 0 8 0 8 0 0 0 0 0 % F
% Gly: 8 0 0 8 16 0 0 8 16 0 8 47 8 0 0 % G
% His: 0 8 0 16 47 0 16 8 0 0 8 0 0 8 0 % H
% Ile: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 16 % K
% Leu: 8 8 0 0 16 0 0 16 0 16 16 0 54 0 62 % L
% Met: 0 0 0 0 0 16 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 8 0 0 16 0 8 8 0 0 0 8 0 % N
% Pro: 0 8 47 0 8 47 47 8 24 8 0 16 0 0 8 % P
% Gln: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 8 % Q
% Arg: 8 0 0 0 0 0 0 0 0 0 8 8 0 0 0 % R
% Ser: 8 70 0 8 8 0 16 47 16 0 0 8 16 62 8 % S
% Thr: 16 0 0 0 0 8 0 0 31 8 0 8 0 8 0 % T
% Val: 0 0 8 0 0 0 8 0 0 0 0 0 0 16 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 8 0 0 0 0 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _